Morphologic and angiographic features of coronary plaque rupture detected by intravascular ultrasound

Akiko Maehara, Gary S. Mintz, Anh B. Bui, Olga R. Walter, Marco T. Castagna, Daniel Canos, August D. Pichard, Lowell F. Satler, Ron Waksman, William O. Suddath, John R. Laird, Kenneth M. Kent, Neil J. Weissman

Research output: Contribution to journalArticlepeer-review

312 Scopus citations


OBJECTIVES: This study was designed to report the clinical and angiographic correlates of plaque rupture detected by intravascular ultrasound (IVUS). BACKGROUND: Acute coronary syndromes result from spontaneous plaque rupture and thrombosis. METHODS: We report 300 plaque ruptures in 257 arteries in 254 patients. Plaque ruptures were detected during pre-intervention IVUS. Standard clinical, angiographic, and IVUS parameters were collected and/or measured. One lesion per patient was analyzed. RESULTS: Multiple ruptures were observed in 39 of 254 patients (15%), 36 in the same artery. Plaque rupture occurred not only in patients with unstable angina (46%) or myocardial infarction (MI, 33%), but also stable angina (11%) or no symptoms (11%). The tear in the fibrous cap could be identified in 157 of 254 patients; 63% occurred at the shoulder of the plaque and 37% in the center of the plaque. Thrombi were more common in patients with unstable angina or MI (p = 0.02) and in multiple ruptures (p = 0.04). The plaque rupture site contained the minimum lumen area (MLA) site in only 28% of patients; rupture sites had larger arterial and lumen areas and more positive remodeling than MLA sites. Intravascular ultrasound plaque rupture strongly correlated with complex angiographic lesion morphology: ulceration in 81%, intimal flap in 40%, thrombus in 7%, and aneurysm in 7%. CONCLUSIONS: Plaque ruptures occur with varying clinical presentations, strongly correlate with angiographic complex lesion morphology, may be multiple, and usually do not cause lumen compromise.

Original languageEnglish (US)
Pages (from-to)904-910
Number of pages7
JournalJournal of the American College of Cardiology
Issue number5
StatePublished - Sep 4 2002
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)


Dive into the research topics of 'Morphologic and angiographic features of coronary plaque rupture detected by intravascular ultrasound'. Together they form a unique fingerprint.

Cite this