Abstract
The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-349 |
| Number of pages | 5 |
| Journal | Biochemical Society Transactions |
| Volume | 28 |
| Issue number | 4 |
| State | Published - 2000 |
Fingerprint
Keywords
- Bone
- Bone morphogenetic proteins (BMPs)
- Cartilage
- Collagen type IV
ASJC Scopus subject areas
- Biochemistry
Cite this
Morphogenetic messages are in the extracellular matrix : Biotechnology from bench to bedside. / Reddi, A Hari.
In: Biochemical Society Transactions, Vol. 28, No. 4, 2000, p. 345-349.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphogenetic messages are in the extracellular matrix
T2 - Biotechnology from bench to bedside
AU - Reddi, A Hari
PY - 2000
Y1 - 2000
N2 - The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.
AB - The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.
KW - Bone
KW - Bone morphogenetic proteins (BMPs)
KW - Cartilage
KW - Collagen type IV
UR - http://www.scopus.com/inward/record.url?scp=0033858996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033858996&partnerID=8YFLogxK
M3 - Article
VL - 28
SP - 345
EP - 349
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - 4
ER -