Morphogenetic messages are in the extracellular matrix: Biotechnology from bench to bedside

Research output: Contribution to journalArticle

59 Scopus citations


The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalBiochemical Society Transactions
Issue number4
StatePublished - 2000



  • Bone
  • Bone morphogenetic proteins (BMPs)
  • Cartilage
  • Collagen type IV

ASJC Scopus subject areas

  • Biochemistry

Cite this