Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys

Eugene Steffey, J. D. BAGGOT, J. H. EISELE, N. WILLITS, M. J. WOLINER, K. A. JARVIS, A. R. ELLIOTT, M. TAGAWA

Research output: Contribution to journalArticle

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Abstract

In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg‐kg‐1 morphine intravenously (i‐v.) and the concurrent effect on Pco2 with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. Paco2 rose at constant MAC with morphine to 55–60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre‐morphine control levels, naloxone immediately reduced Paco2 to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two‐compartment model.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1994

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morphine
Macaca mulatta
Morphine
Isoflurane
isoflurane
Swine
Dogs
swine
dogs
Haplorhini
monkeys
depth of anesthesia
naloxone
Naloxone
pharmacokinetics
Ventilation
Rosa
Anesthesia
Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys. / Steffey, Eugene; BAGGOT, J. D.; EISELE, J. H.; WILLITS, N.; WOLINER, M. J.; JARVIS, K. A.; ELLIOTT, A. R.; TAGAWA, M.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 17, No. 3, 01.01.1994, p. 202-210.

Research output: Contribution to journalArticle

Steffey, E, BAGGOT, JD, EISELE, JH, WILLITS, N, WOLINER, MJ, JARVIS, KA, ELLIOTT, AR & TAGAWA, M 1994, 'Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys', Journal of Veterinary Pharmacology and Therapeutics, vol. 17, no. 3, pp. 202-210. https://doi.org/10.1111/j.1365-2885.1994.tb00234.x
Steffey, Eugene ; BAGGOT, J. D. ; EISELE, J. H. ; WILLITS, N. ; WOLINER, M. J. ; JARVIS, K. A. ; ELLIOTT, A. R. ; TAGAWA, M. / Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys. In: Journal of Veterinary Pharmacology and Therapeutics. 1994 ; Vol. 17, No. 3. pp. 202-210.
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