Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys

Eugene Steffey; J. D. BAGGOT; J. H. EISELE; N. WILLITS; M. J. WOLINER; K. A. JARVIS; A. R. ELLIOTT; M. TAGAWA

doi:10.1111/j.1365-2885.1994.tb00234.x

Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys

Eugene Steffey, J. D. BAGGOT, J. H. EISELE, N. WILLITS, M. J. WOLINER, K. A. JARVIS, A. R. ELLIOTT, M. TAGAWA

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg‐kg^‐1 morphine intravenously (i‐v.) and the concurrent effect on Pco₂ with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. Paco₂ rose at constant MAC with morphine to 55–60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre‐morphine control levels, naloxone immediately reduced Paco₂ to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two‐compartment model.

Original language	English (US)
Pages (from-to)	202-210
Number of pages	9
Journal	Journal of Veterinary Pharmacology and Therapeutics
Volume	17
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2885.1994.tb00234.x
State	Published - Jan 1 1994

ASJC Scopus subject areas

Pharmacology
veterinary(all)

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title = "Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys",

abstract = "In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg‐kg‐1 morphine intravenously (i‐v.) and the concurrent effect on Pco2 with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. Paco2 rose at constant MAC with morphine to 55–60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre‐morphine control levels, naloxone immediately reduced Paco2 to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two‐compartment model.",

author = "Eugene Steffey and BAGGOT, {J. D.} and EISELE, {J. H.} and N. WILLITS and WOLINER, {M. J.} and JARVIS, {K. A.} and ELLIOTT, {A. R.} and M. TAGAWA",

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AU - BAGGOT, J. D.

AU - EISELE, J. H.

AU - WILLITS, N.

AU - WOLINER, M. J.

AU - JARVIS, K. A.

AU - ELLIOTT, A. R.

AU - TAGAWA, M.

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N2 - In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg‐kg‐1 morphine intravenously (i‐v.) and the concurrent effect on Pco2 with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. Paco2 rose at constant MAC with morphine to 55–60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre‐morphine control levels, naloxone immediately reduced Paco2 to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two‐compartment model.

AB - In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg‐kg‐1 morphine intravenously (i‐v.) and the concurrent effect on Pco2 with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. Paco2 rose at constant MAC with morphine to 55–60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre‐morphine control levels, naloxone immediately reduced Paco2 to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two‐compartment model.

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