Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors

Jialing Liu, Jeremy Nickolenko, Frank R Sharp

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Morphine induced the c-fos and junB immediate early genes in neurons of the medial and ventral striatum and nucleus accumbens. Induction of c-fos and junB mRNA and Fos protein was blocked by naloxone, the D1 dopamine (DA) receptor antagonists SCH23390 and SCH39166, and the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK801. SCH23390 attenuated morphine induction of AP-1 binding in striatum, suggesting that c-fos and junB contribute to AP-1 binding. SCH23390 and MK801 did not block morphine induction of c-fos and junB in septum. Since the morphine induction of c-fos and junB in striatum and nucleus accumbens (NA) was similar to that observed with cocaine and amphetamine, these data support current concepts that limbic striatum and NA are among the brain regions that mediate drug abuse. Furthermore, since DA and NMDA receptors may mediate opiate reward and opiate induction of c-fos and junB, the DA/NMDA regulation of c-fos and junB and their target genes may produce long-term changes in the striatal and NA circuits that contribute to opiate drug abuse.

Original languageEnglish (US)
Pages (from-to)8537-8541
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number18
StatePublished - Aug 30 1994
Externally publishedYes

Fingerprint

Opiate Alkaloids
Nucleus Accumbens
N-Methyl-D-Aspartate Receptors
Morphine
Transcription Factor AP-1
Substance-Related Disorders
Dopamine
Corpus Striatum
Excitatory Amino Acid Antagonists
Immediate-Early Genes
Dopamine Antagonists
Amphetamine
N-Methylaspartate
Naloxone
Reward
Cocaine
Neurons
Messenger RNA
Brain
Genes

Keywords

  • basal ganglia
  • dopamine
  • drug abuse
  • immediate early genes
  • opioid

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. / Liu, Jialing; Nickolenko, Jeremy; Sharp, Frank R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 18, 30.08.1994, p. 8537-8541.

Research output: Contribution to journalArticle

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