Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline

Jennifer B. McClure, Gary E. Swan, Lisa Jack, Sheryl L Catz, Susan M. Zbikowski, Tim A. McAfee, Mona Deprey, Julie Richards, Harold Javitz

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Background: Varenicline may be associated with greater mood disturbance and side-effects among smokers with psychiatric history, but empirical evidence is limited. Differential treatment effectiveness by psychiatric history may also exist. OBJECTIVE: To compare mood, prevalence and intensity of treatment side-effects, and abstinence among people with a probable history of major depression (DH+) or not (DH-) who took varenicline and received behavioral smoking cessation treatment. DESIGN: Smokers participated in a randomized behavioral intervention effectiveness trial. Treatment side-effects and outcomes were compared between DH+ and DH- participants (n∈=∈1,117) at 2 days and 3 months after the target quit date. PARTICIPANTS: Smokers recruited from a large regional health plan. Measurements: Change in stress and depression scores, prevalence and intensity of treatment side-effects, and abstinence rates. Results: All side-effects averaged moderate intensity or less and were similar across DH groups, except DH+'s endorsed slightly worse confusion, nausea (adjusted P∈=∈0.04) and trouble sleeping (adjusted P∈=∈0.008) at 21 days. Depression and stress scores declined in both DH groups and an equal proportion of each evidenced new/worsening depressive symptoms. Despite few differences in symptom intensity, more DH+ participants reported recent tension/agitation, irritability/anger, confusion, and depression at 21 days (adjusted P∈<∈0.05), and depression and anxiety (adjusted P∈<∈0.01) at three months. Nonsmoking rates did not differ by DH group at follow-up. CONCLUSION: While some group differences were noted, DH+ smokers did not report qualitatively worse neuropsychiatric symptoms, more new/worsening mood disturbance, or differential abstinence rates compared to DH- smokers.

Original languageEnglish (US)
Pages (from-to)563-569
Number of pages7
JournalJournal of General Internal Medicine
Volume24
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

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Keywords

  • Depression
  • Smoking
  • Varenicline

ASJC Scopus subject areas

  • Internal Medicine

Cite this

McClure, J. B., Swan, G. E., Jack, L., Catz, S. L., Zbikowski, S. M., McAfee, T. A., Deprey, M., Richards, J., & Javitz, H. (2009). Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline. Journal of General Internal Medicine, 24(5), 563-569. https://doi.org/10.1007/s11606-009-0926-8