Mood-elevating effects of opioid analgesics in patients with bipolar disorder

Charles B. Schaffer, Thomas E Nordahl, Linda C. Schaffer, Jeanne Howe

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Opioids can have mood-elevating effects in healthy subjects and have been used successfully to treat refractory depressed patients. A few case reports indicate that opioid analgesics can induce mania. The authors investigated the mood reaction of opioid analgesics in patients with bipolar disorder. Nine (27%) of 33 patients who took opioid analgesics for medical reasons experienced a significant hypomanic/manic reaction, and two other patients reported an antidepressant effect. None of the comparison subjects reported a significant mood reaction from opioid analgesics. These results indicate that opioid analgesics can have an important mood-altering effect on patients with known bipolar disorder.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume19
Issue number4
DOIs
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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