Mood and neuropsychological changes in women with midlife depression treated with escitalopram

Tonita E. Wroolie, Katherine E. Williams, Jennifer Keller, Laurel N. Zappert, Stephanie Crossen, Heather A. Kenna, Margaret F. Reynolds, Natalie L. Rasgon

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE: This study assessed mood and neuropsychological function in a population of middle-aged women with major depressive disorder treated with escitalopram. METHODS: Psychometric data measuring severity of depression were collected from 19 women and neuropsychological data were collected from 17 women aged between 45 and 65 years with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depression in a study in the Behavioral Neuroendocrinology Program at the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine. All women were treated with escitalopram in an open-label design. Mean age was 55.94 years and mean number of years of education was 16.36 years. Diagnosis of major depressive disorder was assessed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and mood was evaluated with the 21-item Hamilton Depression Rating Scale (HAM-D) at baseline and at weekly follow-ups for 12 weeks. Cognition was assessed at baseline and 3 months after treatment using a neuropsychological test battery, which included an abbreviated measure of Full Scale Intelligence Quotient, measures of attention and processing speed, verbal and nonverbal memory, executive functioning, and verbal fluency. Self-report data were collected on current menopause status and current hormone therapy use in the postmenopausal women. Paired sample t tests were used to analyze the change in total HAM-D scores and neuropsychological variables. RESULTS: Statistically significant improvements were found in total HAM-D score, Wechsler Memory Scale III Logical Memory 1st Recall, I, and II scores, Wechsler Memory Scale III Visual Reproduction I scores, and Trail Making Test Part B scores. There was a statistically significant decrease in Controlled Oral Word Association Test FAS scores. CONCLUSIONS: Treatment of depression with escitalopram in a population of middle-aged women was shown to improve mood and cognitive efficiency in complex attention, short- and long-term recall of contextual information, short-term recall of visual information, and cognitive flexibility; however, it was shown to worsen phonemic fluency.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume26
Issue number4
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Citalopram
Depression
Wechsler Scales
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Word Association Tests
Neuroendocrinology
Trail Making Test
Behavioral Sciences
Neuropsychological Tests
Menopause
Intelligence
Psychometrics
Self Report
Cognition
Population
Reproduction
Psychiatry
Therapeutics
Medicine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Mood and neuropsychological changes in women with midlife depression treated with escitalopram. / Wroolie, Tonita E.; Williams, Katherine E.; Keller, Jennifer; Zappert, Laurel N.; Crossen, Stephanie; Kenna, Heather A.; Reynolds, Margaret F.; Rasgon, Natalie L.

In: Journal of Clinical Psychopharmacology, Vol. 26, No. 4, 01.08.2006, p. 361-366.

Research output: Contribution to journalArticle

Wroolie, Tonita E. ; Williams, Katherine E. ; Keller, Jennifer ; Zappert, Laurel N. ; Crossen, Stephanie ; Kenna, Heather A. ; Reynolds, Margaret F. ; Rasgon, Natalie L. / Mood and neuropsychological changes in women with midlife depression treated with escitalopram. In: Journal of Clinical Psychopharmacology. 2006 ; Vol. 26, No. 4. pp. 361-366.
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AU - Wroolie, Tonita E.

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AU - Crossen, Stephanie

AU - Kenna, Heather A.

AU - Reynolds, Margaret F.

AU - Rasgon, Natalie L.

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N2 - OBJECTIVE: This study assessed mood and neuropsychological function in a population of middle-aged women with major depressive disorder treated with escitalopram. METHODS: Psychometric data measuring severity of depression were collected from 19 women and neuropsychological data were collected from 17 women aged between 45 and 65 years with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depression in a study in the Behavioral Neuroendocrinology Program at the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine. All women were treated with escitalopram in an open-label design. Mean age was 55.94 years and mean number of years of education was 16.36 years. Diagnosis of major depressive disorder was assessed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and mood was evaluated with the 21-item Hamilton Depression Rating Scale (HAM-D) at baseline and at weekly follow-ups for 12 weeks. Cognition was assessed at baseline and 3 months after treatment using a neuropsychological test battery, which included an abbreviated measure of Full Scale Intelligence Quotient, measures of attention and processing speed, verbal and nonverbal memory, executive functioning, and verbal fluency. Self-report data were collected on current menopause status and current hormone therapy use in the postmenopausal women. Paired sample t tests were used to analyze the change in total HAM-D scores and neuropsychological variables. RESULTS: Statistically significant improvements were found in total HAM-D score, Wechsler Memory Scale III Logical Memory 1st Recall, I, and II scores, Wechsler Memory Scale III Visual Reproduction I scores, and Trail Making Test Part B scores. There was a statistically significant decrease in Controlled Oral Word Association Test FAS scores. CONCLUSIONS: Treatment of depression with escitalopram in a population of middle-aged women was shown to improve mood and cognitive efficiency in complex attention, short- and long-term recall of contextual information, short-term recall of visual information, and cognitive flexibility; however, it was shown to worsen phonemic fluency.

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