Abstract
Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1%, 14.3%, 25%, 50% or 100%, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13% lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15% and +27%, with an average overestimation of 8%. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8% lower, on average, than homogeneous breast model.
| Original language | English (US) |
|---|---|
| Journal | Physica Medica |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Breast CT
- DgN
- Mean glandular dose
- Patient specific digital breast phantoms
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Physics and Astronomy(all)
Cite this
Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast : Homogeneous and heterogeneous breast models. / Sarno, Antonio; Mettivier, Giovanni; Tucciariello, Raffaele M.; Bliznakova, Kristina; Boone, John M; Sechopoulos, Ioannis; Di Lillo, Francesca; Russo, Paolo.
In: Physica Medica, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast
T2 - Homogeneous and heterogeneous breast models
AU - Sarno, Antonio
AU - Mettivier, Giovanni
AU - Tucciariello, Raffaele M.
AU - Bliznakova, Kristina
AU - Boone, John M
AU - Sechopoulos, Ioannis
AU - Di Lillo, Francesca
AU - Russo, Paolo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1%, 14.3%, 25%, 50% or 100%, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13% lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15% and +27%, with an average overestimation of 8%. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8% lower, on average, than homogeneous breast model.
AB - Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1%, 14.3%, 25%, 50% or 100%, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13% lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15% and +27%, with an average overestimation of 8%. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8% lower, on average, than homogeneous breast model.
KW - Breast CT
KW - DgN
KW - Mean glandular dose
KW - Patient specific digital breast phantoms
UR - http://www.scopus.com/inward/record.url?scp=85048096134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048096134&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2018.05.021
DO - 10.1016/j.ejmp.2018.05.021
M3 - Article
C2 - 29885958
AN - SCOPUS:85048096134
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
ER -