Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

Antonio Sarno, Giovanni Mettivier, Raffaele M. Tucciariello, Kristina Bliznakova, John M Boone, Ioannis Sechopoulos, Francesca Di Lillo, Paolo Russo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1%, 14.3%, 25%, 50% or 100%, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13% lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15% and +27%, with an average overestimation of 8%. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8% lower, on average, than homogeneous breast model.

Original languageEnglish (US)
JournalPhysica Medica
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

X Ray Computed Tomography
breast
cones
Breast
tomography
dosage
evaluation
x rays
coefficients
adipose tissues
Cone-Beam Computed Tomography
scanners
Adipose Tissue
Electrodes
anodes
Air
X-Rays
Skin
air

Keywords

  • Breast CT
  • DgN
  • Mean glandular dose
  • Patient specific digital breast phantoms

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast : Homogeneous and heterogeneous breast models. / Sarno, Antonio; Mettivier, Giovanni; Tucciariello, Raffaele M.; Bliznakova, Kristina; Boone, John M; Sechopoulos, Ioannis; Di Lillo, Francesca; Russo, Paolo.

In: Physica Medica, 01.01.2018.

Research output: Contribution to journalArticle

Sarno, Antonio ; Mettivier, Giovanni ; Tucciariello, Raffaele M. ; Bliznakova, Kristina ; Boone, John M ; Sechopoulos, Ioannis ; Di Lillo, Francesca ; Russo, Paolo. / Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast : Homogeneous and heterogeneous breast models. In: Physica Medica. 2018.
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abstract = "Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1{\%}, 14.3{\%}, 25{\%}, 50{\%} or 100{\%}, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13{\%} lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15{\%} and +27{\%}, with an average overestimation of 8{\%}. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8{\%} lower, on average, than homogeneous breast model.",
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AU - Sarno, Antonio

AU - Mettivier, Giovanni

AU - Tucciariello, Raffaele M.

AU - Bliznakova, Kristina

AU - Boone, John M

AU - Sechopoulos, Ioannis

AU - Di Lillo, Francesca

AU - Russo, Paolo

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