Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy

Kuang-Yu Jen, Oren K. Fix, Erina N. Foster, Zoltan G. Laszik, Linda D. Ferrell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Immunotactoid deposits are defined by their ultrastructural appearance and are characterized by microtubular or cylindrical structures typically measuring greater than 30nm in diameter. Although a rare entity, immunotactoid deposition most often manifests as immunotactoid glomerulopathy and is associated with underlying lymphoplasmacytic disorders. Corneal immunotactoid deposition known as immunotactoid keratopathy has also been reported in patients with paraproteinemia. Here, we describe the first reported case of immunotactoid deposition in the stomach. The deposits were composed solely of kappa immunoglobulin light chains without significant lambda light chain or immunoglobulin heavy chain components. The patient displayed no renal signs or symptoms, and additional thorough clinical examination failed to detect any evidence of a paraproteinemia or plasma cell dyscrasia. Thus, the gastric immunotactoid deposits in this case appear to be an isolated finding of light chain deposition, of which the significance and etiology are unclear.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalUltrastructural Pathology
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Paraproteinemias
Stomach
Light
Immunoglobulin kappa-Chains
Immunoglobulin Heavy Chains
Signs and Symptoms
Kidney

Keywords

  • Deposition
  • Gastropathy
  • Glomerulopathy
  • Immunotactoid
  • Light chain
  • Microtubules

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

Cite this

Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy. / Jen, Kuang-Yu; Fix, Oren K.; Foster, Erina N.; Laszik, Zoltan G.; Ferrell, Linda D.

In: Ultrastructural Pathology, Vol. 39, No. 1, 01.01.2015, p. 62-68.

Research output: Contribution to journalArticle

Jen, Kuang-Yu ; Fix, Oren K. ; Foster, Erina N. ; Laszik, Zoltan G. ; Ferrell, Linda D. / Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy. In: Ultrastructural Pathology. 2015 ; Vol. 39, No. 1. pp. 62-68.
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