The mammalian immune system, an evolutionary development as complex as the many creatures that carry it, includes a huge repertoire of antibodies, to combine with whatever antigens the animal encounters. Cloned cells, of mouse or other origin, produce monoclonal antibodies (MoAb). MoAbs are radiolabeled for imaging, currently either by iodination or by chelation with radiometals such as indium-111. Most imaging problems stem from circulating background and uptake by nontargeted tissues. These may be addressed by judicious choices of antibody or antibody fragment, of preparation methods, of antibody mass administered, of imaging time, and other variables that are generally peculiar to each MoAb and not entirely predictable. A major clinical use of MoAb imaging at this time is in the staging and management of cancer. Other uses coming into prominence are the mapping of myocardial infarcts, of thromboembolism, and of inflammatory processes. The advance of this technology has been so rapid that currently available clinical reports understate the clinical utility already available.
|Original language||English (US)|
|Number of pages||13|
|State||Published - 1989|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging