Monoclonal anti acetylcholine receptor antibodies with differing capacities to induce experimental autoimmune myasthenia gravis

C. M. Gomez, David P Richman

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

To study the characteristics of the individual autoantibodies that are important in the development of an autoimmune disease, we produced 26 anti-acetylcholine receptor (anti-AChR) monoclonal antibodies (mcAb) and studied the experimental autoimmune myasthenia gravis (EAMG) induced by a number of them. The mcAb reactive with mammalian acetylcholine receptor (M-AChR) exhibited a wide range of dissociation rates from in situ M-AChR of motor endplates. All anti-M-AChR mcAb were capable of producing at least some degree of histopathologic change at the endplate indicative of EAMG, but their potencies varied markedly. One mcAb induced, even at large doses, only minor macrophage invasion without clinical or electromyographic effect. Other induced severe EAMG, and even death, at 1/200th the dose. Low potency was associated with high rate of mcAb dissociation from antigen. High potency was associated with intermediate avidity, not high avidity. These observations suggest that in EAMG, and perhaps in myasthenia gravis, the characteristics of the individual antibodies making up the autoimmune response can determine the severity of the autoimmune disease.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalJournal of Immunology
Volume135
Issue number1
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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