Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia

David P Richman, Christopher M. Gomez, Phillip W. Berman, Steven A. Burres, Frank W. Fitch, Barry G W Arnason

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Myasthenie gravis (MG) is a disease which occurs as a consequence of an autoimmune response directed against the nicotinic acetylcholine receptor (AChR) of the myoneural junction1-3. Antisera raised against complex antigens such as AChR comprise a mixture of antibodies reactive with various determinants on the antigen molecule. The antibodies against any single determinant may be of several immunoglobulin classes and idiotypes. Antibodies produced by cloned lymphocyte-myeloma hybridoma cell lines have provided a way of analysing the diverse components making up a polyclonal antiserum4 and assessing the relative contribution made by each to the overall immune reaction in vivo5,6. We have applied this technique to the investigation of the autoimmune response in MG. We demonstrate here that certain monoclonal anti-Torpedo AChR antibodies, when injected intravenously into normal rats, induce an acute myasthenie syndrome. Thus binding of a single molecular species of antibody reactive with a single antigenic determinant can result in all of the manifestations of an autoimmune disease.

Original languageEnglish (US)
Pages (from-to)738-739
Number of pages2
JournalNature
Volume286
Issue number5774
DOIs
StatePublished - 1980
Externally publishedYes

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Autoimmune Experimental Myasthenia Gravis
Cholinergic Receptors
Antibodies
Autoimmunity
Immunoglobulin Idiotypes
Antigens
Torpedo
Immunoglobulin Isotypes
Hybridomas
Nicotinic Receptors
Autoimmune Diseases
Immune Sera
Epitopes
Lymphocytes
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Richman, D. P., Gomez, C. M., Berman, P. W., Burres, S. A., Fitch, F. W., & Arnason, B. G. W. (1980). Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia. Nature, 286(5774), 738-739. https://doi.org/10.1038/286738a0

Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia. / Richman, David P; Gomez, Christopher M.; Berman, Phillip W.; Burres, Steven A.; Fitch, Frank W.; Arnason, Barry G W.

In: Nature, Vol. 286, No. 5774, 1980, p. 738-739.

Research output: Contribution to journalArticle

Richman, DP, Gomez, CM, Berman, PW, Burres, SA, Fitch, FW & Arnason, BGW 1980, 'Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia', Nature, vol. 286, no. 5774, pp. 738-739. https://doi.org/10.1038/286738a0
Richman, David P ; Gomez, Christopher M. ; Berman, Phillip W. ; Burres, Steven A. ; Fitch, Frank W. ; Arnason, Barry G W. / Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia. In: Nature. 1980 ; Vol. 286, No. 5774. pp. 738-739.
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