Monitoring of serum markers for fibrosis during CCl4-induced liver damage. Effects of anti-fibrotic agents

Zhao Jiang, Da yu You, Xiang chi Chen, Jian Wu

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Liver fibrosis was induced in rats by repeated peritoneal injections of carbon tetrachloride (CCl4) over a period of 2-11 weeks. Serum procollagen III peptide (SPIIINP), prolidase (SP) and alanine aminotransferase (SALT) levels were monitored during the period of induction. The extent of fibrosis was semi-quantitatively estimated after collagen staining, and the anti-fibrotic effects of 16,16-dimethyl prostaglandin E2 (DMPGE2), colchicine, and zinc sulphate were studied. SPIIINP and SP were increased the first 2 weeks after CCl4 administration and peaked at 6 weeks. Alterations in SPIIINP and SP correlated well to the semi-quantitative histological score of liver sections during the first 6 weeks, and SP was positively related to SPIIINP throughout the whole induction period. DMPGE2 decreased SPIIINP, SP and SALT significantly in addition to a markedly decreased formation of liver collagens. Colchicine had a similar but less dramatic effect, whereas zinc sulphate only reduced SPIIINP without influencing liver damage. In conclusion SPIIINP seems to be a valuable indicator of liver fibrogenesis, and SP may play a limited role in indicating accelerated collagen metabolism in the liver. DMPGE2 obviously inhibited the production of collagens induced by CCl4. Colchicine also had an apparent effect on liver fibrosis, whereas zinc sulphate merely seemed to postpone it.

Original languageEnglish (US)
Pages (from-to)282-289
Number of pages8
JournalJournal of Hepatology
Volume16
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • 16,16-Dimethyl prostaglandin E
  • Colchicine
  • Liver fibrosis
  • Procollagen III peptide
  • Prolidase
  • Zinc sulphate

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Monitoring of serum markers for fibrosis during CCl<sub>4</sub>-induced liver damage. Effects of anti-fibrotic agents'. Together they form a unique fingerprint.

  • Cite this