Abstract
Immunoassays offer selective, sensitive and low-cost tools for the assessment of pesticide exposure through the measurement of parent compounds or key metabolites in biological fluids such as urine, blood or saliva. Recently conducted biomonitoring studies for paraquat and atrazine illustrate the strengths and weaknesses of the immunochemical approach. Development for improved assay throughput and sensitivity includes substitution of enzyme labels with fluorescent nanoparticle probes or luminescent acridinium labels together with the use of automated immunoanalyzers, immunosensors or microchips with flow-through systems.
| Original language | English (US) |
|---|---|
| Title of host publication | ACS Symposium Series |
| Pages | 141-156 |
| Number of pages | 16 |
| Volume | 951 |
| State | Published - 2007 |
Publication series
| Name | ACS Symposium Series |
|---|---|
| Volume | 951 |
| ISSN (Print) | 00976156 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Monitoring human exposure to pesticides using immunoassay. / Koivunen, Marja E.; Gee, Shirley J.; Nichkova, Mikaela; Ahn, Ki Chang; Hammock, Bruce D.
ACS Symposium Series. Vol. 951 2007. p. 141-156 (ACS Symposium Series; Vol. 951).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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TY - GEN
T1 - Monitoring human exposure to pesticides using immunoassay
AU - Koivunen, Marja E.
AU - Gee, Shirley J.
AU - Nichkova, Mikaela
AU - Ahn, Ki Chang
AU - Hammock, Bruce D.
PY - 2007
Y1 - 2007
N2 - Immunoassays offer selective, sensitive and low-cost tools for the assessment of pesticide exposure through the measurement of parent compounds or key metabolites in biological fluids such as urine, blood or saliva. Recently conducted biomonitoring studies for paraquat and atrazine illustrate the strengths and weaknesses of the immunochemical approach. Development for improved assay throughput and sensitivity includes substitution of enzyme labels with fluorescent nanoparticle probes or luminescent acridinium labels together with the use of automated immunoanalyzers, immunosensors or microchips with flow-through systems.
AB - Immunoassays offer selective, sensitive and low-cost tools for the assessment of pesticide exposure through the measurement of parent compounds or key metabolites in biological fluids such as urine, blood or saliva. Recently conducted biomonitoring studies for paraquat and atrazine illustrate the strengths and weaknesses of the immunochemical approach. Development for improved assay throughput and sensitivity includes substitution of enzyme labels with fluorescent nanoparticle probes or luminescent acridinium labels together with the use of automated immunoanalyzers, immunosensors or microchips with flow-through systems.
UR - http://www.scopus.com/inward/record.url?scp=36749094076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749094076&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:36749094076
SN - 0841239746
SN - 9780841239746
VL - 951
T3 - ACS Symposium Series
SP - 141
EP - 156
BT - ACS Symposium Series
ER -