Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface

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39 Citations (Scopus)

Abstract

Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.

Original languageEnglish (US)
Pages (from-to)217-231
Number of pages15
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume36
Issue number3
DOIs
StatePublished - May 2013

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Oocysts
Toxoplasma
Toxoplasma gondii
oocysts
animals
stakeholders
death
Survival
Infection
infection
Population

Keywords

  • Climate change
  • Environmental resistance
  • Land use change
  • Modeling
  • Molecular characterization
  • One Health
  • Oocyst
  • Toxoplasma gondii
  • Transport
  • Zoonotic disease

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases
  • Immunology and Allergy
  • veterinary(all)

Cite this

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abstract = "Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.",
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