Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry

J. N. Quong, M. G. Knize, K. S. Kulp, K. J. Wu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalApplied Surface Science
Volume231-232
DOIs
StatePublished - Jun 15 2004
Externally publishedYes

Fingerprint

Mutagens
carcinogens
Carcinogens
Secondary ion mass spectrometry
breast
Pyridine
secondary ion mass spectrometry
Amines
mutagens
cancer
Cells
Imaging techniques
rodents
Molecules
cells
molecules
pyridines
amines
Rodentia
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

Keywords

  • Imaging
  • MCF-7 cell
  • TOF-SIMS

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Condensed Matter Physics

Cite this

Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry. / Quong, J. N.; Knize, M. G.; Kulp, K. S.; Wu, K. J.

In: Applied Surface Science, Vol. 231-232, 15.06.2004, p. 424-427.

Research output: Contribution to journalArticle

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AU - Wu, K. J.

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