Abstract
Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 424-427 |
| Number of pages | 4 |
| Journal | Applied Surface Science |
| Volume | 231-232 |
| DOIs | |
| State | Published - Jun 15 2004 |
| Externally published | Yes |
Keywords
- Imaging
- MCF-7 cell
- TOF-SIMS
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Surfaces, Coatings and Films
- Condensed Matter Physics
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Cite this
Quong, J. N., Knize, M. G., Kulp, K. S., & Wu, K. J. (2004). Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry. Applied Surface Science, 231-232, 424-427. https://doi.org/10.1016/j.apsusc.2004.03.156