Abstract
Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 424-427 |
| Number of pages | 4 |
| Journal | Applied Surface Science |
| Volume | 231-232 |
| DOIs | |
| State | Published - Jun 15 2004 |
| Externally published | Yes |
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Keywords
- Imaging
- MCF-7 cell
- TOF-SIMS
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Surfaces, Coatings and Films
- Condensed Matter Physics
Cite this
Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry. / Quong, J. N.; Knize, M. G.; Kulp, K. S.; Wu, K. J.
In: Applied Surface Science, Vol. 231-232, 15.06.2004, p. 424-427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry
AU - Quong, J. N.
AU - Knize, M. G.
AU - Kulp, K. S.
AU - Wu, K. J.
PY - 2004/6/15
Y1 - 2004/6/15
N2 - Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.
AB - Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.
KW - Imaging
KW - MCF-7 cell
KW - TOF-SIMS
UR - http://www.scopus.com/inward/record.url?scp=2942534275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942534275&partnerID=8YFLogxK
U2 - 10.1016/j.apsusc.2004.03.156
DO - 10.1016/j.apsusc.2004.03.156
M3 - Article
VL - 231-232
SP - 424
EP - 427
JO - Applied Surface Science
JF - Applied Surface Science
SN - 0169-4332
ER -