Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry

J. N. Quong, M. G. Knize, K. S. Kulp, K. J. Wu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalApplied Surface Science
Volume231-232
DOIs
StatePublished - Jun 15 2004
Externally publishedYes

Keywords

  • Imaging
  • MCF-7 cell
  • TOF-SIMS

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Molecule-specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry'. Together they form a unique fingerprint.

  • Cite this