Molecular tools for targeted imaging and therapy of cancer

Claude F. Meares, A. J. Chmura, Molly S. Orton, Todd M. Corneillie, Paul A. Whetstone

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Here we review an approach to the design and production of antibody/ligand pairs for use in cell targeting procedures, to achieve functional affinity far greater than avidin/biotin. Using fundamental chemical principles, we have developed antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate. By eliminating the dissociation of the ligand from the antibody, we have made the affinity functionally infinite. This methodology is applicable to other biological binding pairs.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalJournal of Molecular Recognition
Volume16
Issue number5
DOIs
StatePublished - Sep 2003

Fingerprint

Antibodies
Ligands
Imaging techniques
Immunologic Techniques
Neoplasms
Antibody Specificity
Avidin
Biotin
Antibody Formation
Therapeutics

Keywords

  • Antibody
  • Infinite affinity
  • Metal chelate
  • Nuclear imaging
  • Radiotherapy

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Computer Vision and Pattern Recognition
  • Immunology
  • Molecular Biology

Cite this

Meares, C. F., Chmura, A. J., Orton, M. S., Corneillie, T. M., & Whetstone, P. A. (2003). Molecular tools for targeted imaging and therapy of cancer. Journal of Molecular Recognition, 16(5), 255-259. https://doi.org/10.1002/jmr.634

Molecular tools for targeted imaging and therapy of cancer. / Meares, Claude F.; Chmura, A. J.; Orton, Molly S.; Corneillie, Todd M.; Whetstone, Paul A.

In: Journal of Molecular Recognition, Vol. 16, No. 5, 09.2003, p. 255-259.

Research output: Contribution to journalArticle

Meares, CF, Chmura, AJ, Orton, MS, Corneillie, TM & Whetstone, PA 2003, 'Molecular tools for targeted imaging and therapy of cancer', Journal of Molecular Recognition, vol. 16, no. 5, pp. 255-259. https://doi.org/10.1002/jmr.634
Meares CF, Chmura AJ, Orton MS, Corneillie TM, Whetstone PA. Molecular tools for targeted imaging and therapy of cancer. Journal of Molecular Recognition. 2003 Sep;16(5):255-259. https://doi.org/10.1002/jmr.634
Meares, Claude F. ; Chmura, A. J. ; Orton, Molly S. ; Corneillie, Todd M. ; Whetstone, Paul A. / Molecular tools for targeted imaging and therapy of cancer. In: Journal of Molecular Recognition. 2003 ; Vol. 16, No. 5. pp. 255-259.
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