Molecular tools for targeted imaging and therapy of cancer

Claude F. Meares, A. J. Chmura, Molly S. Orton, Todd M. Corneillie, Paul A. Whetstone

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Here we review an approach to the design and production of antibody/ligand pairs for use in cell targeting procedures, to achieve functional affinity far greater than avidin/biotin. Using fundamental chemical principles, we have developed antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate. By eliminating the dissociation of the ligand from the antibody, we have made the affinity functionally infinite. This methodology is applicable to other biological binding pairs.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalJournal of Molecular Recognition
Issue number5
StatePublished - Sep 2003


  • Antibody
  • Infinite affinity
  • Metal chelate
  • Nuclear imaging
  • Radiotherapy

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Computer Vision and Pattern Recognition
  • Immunology
  • Molecular Biology


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