Molecular thermodynamics using nuclear magnetic resonance (NMR) spectroscopy

Research output: Contribution to journalReview article

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is perhaps the most widely used technology from the undergraduate teaching labs in organic chemistry to advanced research for the determination of three-dimensional structure as well as dynamics of biomolecular systems… The NMR spectrum of a molecule under a given experimental condition is unique, providing both quantitative and structural information. In particular, the quantitative nature of NMR spectroscopy offers the ability to follow a reaction pathway of the given molecule in a dynamic process under well-defined experimental conditions. To highlight the use of NMR when determining the molecular thermodynamic parameters, a review of three distinct applications developed from our laboratory is presented. These applications include the thermodynamic parameters of (a) molecular oxidation from time-dependent kinetics, (b) intramolecular rotation, and (c) intermolecular exchange. An experimental overview and the method of data analysis are provided so that these applications can be adopted in a range of molecular systems.

Original languageEnglish (US)
Article number13
JournalInventions
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Nuclear magnetic resonance spectroscopy
Thermodynamics
Nuclear magnetic resonance
Molecules
Teaching
Oxidation
Kinetics
Organic Chemistry

Keywords

  • Chemical exchange
  • Eyring equation
  • NMR
  • Thermodynamics

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Molecular thermodynamics using nuclear magnetic resonance (NMR) spectroscopy. / Krishnan, Viswanathan V.

In: Inventions, Vol. 4, No. 1, 13, 01.03.2019.

Research output: Contribution to journalReview article

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