Molecular targets, pathways, and therapeutic implications for hepatocellular carcinoma

Jun Gong, Jeremy Chuang, May Cho, Kyra Toomey, Andrew Hendifar, Daneng Li

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer mortality worldwide. While significant advances have been made for the treatment of advanced hepatocellular carcinoma in the past few years, the prognosis remains poor and effective biomarkers to guide selection of therapies remain noticeably absent. However, several targeted therapies have been approved in the past few years that have improved the outlook for this disease. In this review, we will highlight the recent therapies approved for the treatment of advanced HCC and discuss promising therapeutic options, targets, and pathways for drug development and consideration for future clinical trials.

    Original languageEnglish (US)
    Article number5232
    Pages (from-to)1-18
    Number of pages18
    JournalInternational journal of molecular sciences
    Volume21
    Issue number15
    DOIs
    StatePublished - Aug 1 2020

    Keywords

    • Biomarkers
    • Cancer
    • Gastrointestinal
    • Hepatocellular
    • Unresectable

    ASJC Scopus subject areas

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry

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