Molecular targeting in childhood malignancies using nanoparticles

Noriko Satake, Gustavo Barisone, Elva D Diaz, Nitin Nitin, Jan Nolta, Kit Lam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume8373
DOIs
StatePublished - 2012
EventMicro- and Nanotechnology Sensors, Systems, and Applications IV - Baltimore, MD, United States
Duration: Apr 23 2012Apr 27 2012

Other

OtherMicro- and Nanotechnology Sensors, Systems, and Applications IV
CountryUnited States
CityBaltimore, MD
Period4/23/124/27/12

Keywords

  • Acute lymphoblastic leukemia
  • Leukemia-specific ligand
  • Nanoparticles
  • SiRNA
  • Targeted therapy

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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  • Cite this

    Satake, N., Barisone, G., Diaz, E. D., Nitin, N., Nolta, J., & Lam, K. (2012). Molecular targeting in childhood malignancies using nanoparticles. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 8373). [83730N] https://doi.org/10.1117/12.920917