Molecular targeting in childhood malignancies using nanoparticles

Noriko Satake; Gustavo Barisone; Elva D Diaz; Nitin Nitin; Jan Nolta; Kit Lam

doi:10.1117/12.920917

Molecular targeting in childhood malignancies using nanoparticles

Noriko Satake, Gustavo Barisone, Elva D Diaz, Nitin Nitin, Jan Nolta, Kit Lam

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8373
DOIs	https://doi.org/10.1117/12.920917
State	Published - 2012
Event	Micro- and Nanotechnology Sensors, Systems, and Applications IV - Baltimore, MD, United States Duration: Apr 23 2012 → Apr 27 2012

Other

Other	Micro- and Nanotechnology Sensors, Systems, and Applications IV
Country	United States
City	Baltimore, MD
Period	4/23/12 → 4/27/12

Keywords

Acute lymphoblastic leukemia
Leukemia-specific ligand
Nanoparticles
SiRNA
Targeted therapy

ASJC Scopus subject areas

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

Access to Document

10.1117/12.920917

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Cite this

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title = "Molecular targeting in childhood malignancies using nanoparticles",

abstract = "The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.",

keywords = "Acute lymphoblastic leukemia, Leukemia-specific ligand, Nanoparticles, SiRNA, Targeted therapy",

author = "Noriko Satake and Gustavo Barisone and Diaz, {Elva D} and Nitin Nitin and Jan Nolta and Kit Lam",

year = "2012",

doi = "10.1117/12.920917",

language = "English (US)",

isbn = "9780819490513",

volume = "8373",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Micro- and Nanotechnology Sensors, Systems, and Applications IV ; Conference date: 23-04-2012 Through 27-04-2012",

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TY - GEN

T1 - Molecular targeting in childhood malignancies using nanoparticles

AU - Satake, Noriko

AU - Barisone, Gustavo

AU - Diaz, Elva D

AU - Nitin, Nitin

AU - Nolta, Jan

AU - Lam, Kit

PY - 2012

Y1 - 2012

N2 - The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.

AB - The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.

KW - Acute lymphoblastic leukemia

KW - Leukemia-specific ligand

KW - Nanoparticles

KW - SiRNA

KW - Targeted therapy

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DO - 10.1117/12.920917

M3 - Conference contribution

AN - SCOPUS:84863956937

SN - 9780819490513

VL - 8373

BT - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Micro- and Nanotechnology Sensors, Systems, and Applications IV

Y2 - 23 April 2012 through 27 April 2012

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