Abstract
The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.
Original language | English (US) |
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Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 8373 |
DOIs | |
State | Published - 2012 |
Event | Micro- and Nanotechnology Sensors, Systems, and Applications IV - Baltimore, MD, United States Duration: Apr 23 2012 → Apr 27 2012 |
Other
Other | Micro- and Nanotechnology Sensors, Systems, and Applications IV |
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Country | United States |
City | Baltimore, MD |
Period | 4/23/12 → 4/27/12 |
Keywords
- Acute lymphoblastic leukemia
- Leukemia-specific ligand
- Nanoparticles
- SiRNA
- Targeted therapy
ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics