Molecular release from patterned nanoporous gold thin films

Ozge Kurtulus, Pallavi Daggumati, Erkin Seker

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Nanostructured materials have shown significant potential for biomedical applications that require high loading capacity and controlled release of drugs. Nanoporous gold (np-Au), produced by an alloy corrosion process, is a promising novel material that benefits from compatibility with microfabrication, tunable pore morphology, electrical conductivity, well-established gold-thiol conjugate chemistry, and biocompatibility. While np-Au's non-biological applications are abundant, its performance in the biomedical field is nascent. In this work, we employ a combination of techniques including nanoporous thin film synthesis, quantitative electron microscopy, fluorospectrometry, and electrochemical surface characterization to study loading capacity and molecular release kinetics as a function of film properties and discuss underlying mechanisms. The sub-micron-thick sputter-coated nanoporous gold films provide small-molecule loading capacities up to 1.12 μg cm-2 and molecular release half-lives between 3.6 hours to 12.8 hours. A systematic set of studies reveals that effective surface area of the np-Au thin films on glass substrates plays the largest role in determining loading capacity. The release kinetics on the other hand depends on a complex interplay of micro- and nano-scale morphological features.

Original languageEnglish (US)
Pages (from-to)7062-7071
Number of pages10
JournalNanoscale
Volume6
Issue number12
DOIs
StatePublished - Jun 21 2014

ASJC Scopus subject areas

  • Materials Science(all)

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