Molecular pockets derived from cholic acid as chemosensors for metal ions

Jiawei Zhang, Juntao Luo, X. X. Zhu, Matthias J N Junk, Dariush Hinderberger

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Molecular pockets in the form of a tripod made of cholic acid were found to be able to solubilize pyrene in polar media as a result of the facial amphiphilicity of bile acids. The trimer containing 1,2,3-triazole groups can complex with heavy metal ions, as clearly shown by electron paramagnetic resonance spectroscopy. Both the metal cation and the pyrene molecule can be brought close together in the cavity formed by the cholic acid trimer, resulting in significantly improved efficiency for fluorescence quenching of pyrene. The decrease of fluorescence intensity can be used for the detection of heavy metal ions, and the detection limit is about 1 μM in water, suggesting the usefulness of such molecules as chemosensors for such metal ions. A different trimer without the coordinating triazole groups is shown to shield pyrene away from metal ions, causing a much reduced fluorescence quenching.

Original languageEnglish (US)
Pages (from-to)2958-2962
Number of pages5
Issue number4
StatePublished - Feb 16 2010

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy


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