Molecular nutrition fats: Lipoprotein(a)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since its discovery in 1963, our understanding of lipoprotein(a) [Lp(a)] has evolved from an antigenic component to a highly heritable biological trait with a risk factor role in atherosclerotic cardiovascular disease (CVD). However, much still needs to be done in understanding its physiological functions. The LPA gene diverged from the plasminogen gene, likely twice during its evolution, early in hedgehogs and later in a subset of primates. Lp(a) presents a unique setting as a lipoprotein under strong genetic control and with less likelihood of levels being influenced by lifestyles and lipid-lowering therapies. Recent developments, including PCSK9 inhibitors, open novel possibilities for intervention. Other notable Lp(a) features include an intraindividual stability across the lifespan, presence of a 1000-fold interindividual variability, a distinct ethnic-specific difference, and a strong impact by a size polymorphism in the LPA gene. The interest in Lp(a) has expanded beyond CVD to kidney/liver disease, diabetes, and inflammatory conditions.

Original languageEnglish (US)
Title of host publicationThe Molecular Nutrition of Fats
PublisherElsevier
Pages177-187
Number of pages11
ISBN (Electronic)9780128112977
ISBN (Print)9780128112984
DOIs
StatePublished - Jan 1 2018

Keywords

  • Apo(a)
  • Cardiovascular disease
  • HDL
  • Kringles
  • LDL
  • Lipoproteins
  • Lp(a)
  • Statins

ASJC Scopus subject areas

  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Molecular nutrition fats: Lipoprotein(a)'. Together they form a unique fingerprint.

  • Cite this