Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair

Stephen C. Kowalczykowski

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The crystal structure of the central region of Rad51 bound to a BRC peptide from BRCA2 shows that the BRC peptide mimics a structural motif within Rad51 and can thereby regulate assembly of the Rad51 nucleoprotein filament needed for DNA repair.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalNature Structural Biology
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint

Molecular Mimicry
Recombinational DNA Repair
Repair
Peptides
Nucleoproteins
DNA
DNA Repair
Crystal structure

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair. / Kowalczykowski, Stephen C.

In: Nature Structural Biology, Vol. 9, No. 12, 01.12.2002, p. 897-899.

Research output: Contribution to journalArticle

Kowalczykowski, Stephen C. / Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair. In: Nature Structural Biology. 2002 ; Vol. 9, No. 12. pp. 897-899.
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