Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair

Stephen C. Kowalczykowski

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The crystal structure of the central region of Rad51 bound to a BRC peptide from BRCA2 shows that the BRC peptide mimics a structural motif within Rad51 and can thereby regulate assembly of the Rad51 nucleoprotein filament needed for DNA repair.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalNature Structural Biology
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2002

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ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

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