Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair

Stephen C. Kowalczykowski

doi:10.1038/nsb1202-897

Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair

Stephen C. Kowalczykowski

Microbiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The crystal structure of the central region of Rad51 bound to a BRC peptide from BRCA2 shows that the BRC peptide mimics a structural motif within Rad51 and can thereby regulate assembly of the Rad51 nucleoprotein filament needed for DNA repair.

Original language	English (US)
Pages (from-to)	897-899
Number of pages	3
Journal	Nature Structural Biology
Volume	9
Issue number	12
DOIs	https://doi.org/10.1038/nsb1202-897
State	Published - Dec 1 2002

ASJC Scopus subject areas

Biochemistry
Structural Biology
Genetics

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title = "Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair",

abstract = "The crystal structure of the central region of Rad51 bound to a BRC peptide from BRCA2 shows that the BRC peptide mimics a structural motif within Rad51 and can thereby regulate assembly of the Rad51 nucleoprotein filament needed for DNA repair.",

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Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair

Abstract

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