Abstract
Nerve damage during growth and development has a uniquely detrimental effect on limb function, at least partially due to the adverse consequences of the lack of target-tissue innervation during nerve regeneration. Facilitation of nerve regeneration in the developing infant requires a different approach than it does in adults because of differences in the physiology of neonatal nerves and target tissues. The results of surgical intervention to treat nerve damage at the level of the brachial plexus are suboptimal; novel concepts, such as manipulating the nerve-regeneration environment, are on the horizon, but first these mechanisms must be better understood, including with regard to how they differ in the immature nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 87-89 |
| Number of pages | 3 |
| Journal | Journal of Bone and Joint Surgery - Series A |
| Volume | 91 |
| Issue number | SUPPL. 4 |
| DOIs | |
| State | Published - Jul 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
- Medicine(all)
Cite this
Molecular mechanisms to improve nerve regeneration following damage to the immature peripheral nervous system. / Bannerman, Peter; James, Michelle.
In: Journal of Bone and Joint Surgery - Series A, Vol. 91, No. SUPPL. 4, 01.07.2009, p. 87-89.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular mechanisms to improve nerve regeneration following damage to the immature peripheral nervous system
AU - Bannerman, Peter
AU - James, Michelle
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Nerve damage during growth and development has a uniquely detrimental effect on limb function, at least partially due to the adverse consequences of the lack of target-tissue innervation during nerve regeneration. Facilitation of nerve regeneration in the developing infant requires a different approach than it does in adults because of differences in the physiology of neonatal nerves and target tissues. The results of surgical intervention to treat nerve damage at the level of the brachial plexus are suboptimal; novel concepts, such as manipulating the nerve-regeneration environment, are on the horizon, but first these mechanisms must be better understood, including with regard to how they differ in the immature nervous system.
AB - Nerve damage during growth and development has a uniquely detrimental effect on limb function, at least partially due to the adverse consequences of the lack of target-tissue innervation during nerve regeneration. Facilitation of nerve regeneration in the developing infant requires a different approach than it does in adults because of differences in the physiology of neonatal nerves and target tissues. The results of surgical intervention to treat nerve damage at the level of the brachial plexus are suboptimal; novel concepts, such as manipulating the nerve-regeneration environment, are on the horizon, but first these mechanisms must be better understood, including with regard to how they differ in the immature nervous system.
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UR - http://www.scopus.com/inward/citedby.url?scp=67651173337&partnerID=8YFLogxK
U2 - 10.2106/JBJS.I.00279
DO - 10.2106/JBJS.I.00279
M3 - Article
C2 - 19571074
AN - SCOPUS:67651173337
VL - 91
SP - 87
EP - 89
JO - Journal of Bone and Joint Surgery - American Volume
JF - Journal of Bone and Joint Surgery - American Volume
SN - 0021-9355
IS - SUPPL. 4
ER -