Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion

Yutaka Matsui, Shiori Kyoi, Hiromitsu Takagi, Chiao Po Hsu, Nirmala Hariharan, Tetsuro Ago, Stephen F. Vatner, Junichi Sadoshima

Research output: Contribution to journalReview article

144 Scopus citations

Abstract

Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a homeostatic role at basal levels, and the absence of autophagy causes cardiac dysfunction and the development of cardiomyopathy. Autophagy is induced during myocardial ischemia and further enhanced by reperfusion. Although induction of autophagy during the ischemic phase is protective, further enhancement of autophagy during the reperfusion phase may induce cell death and appears to be detrimental. In this review we discuss the functional significance of autophagy and the underlying signaling mechanism in the heart during ischemia/reperfusion.

Original languageEnglish (US)
Pages (from-to)409-415
Number of pages7
JournalAutophagy
Volume4
Issue number4
DOIs
StatePublished - May 16 2008
Externally publishedYes

Keywords

  • AMPK
  • Apoptosis
  • Autophagy
  • Beclin1
  • Heart
  • Ischemia
  • Reperfusion

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Matsui, Y., Kyoi, S., Takagi, H., Hsu, C. P., Hariharan, N., Ago, T., Vatner, S. F., & Sadoshima, J. (2008). Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy, 4(4), 409-415. https://doi.org/10.4161/auto.5638