Molecular mechanism of TRP channels

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131 Citations (Scopus)

Abstract

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of physical and chemical stimuli. They are involved in the formation of sight, hearing, touch, smell, taste, temperature, and pain sensation. TRP channels also play fundamental roles in cell signaling and allow the host cell to respond to benign or harmful environmental changes. As TRP channel activation is controlled by very diverse processes and, in many cases, exhibits complex polymodal properties, understanding how each TRP channel responds to its unique forms of activation energy is both crucial and challenging. The past two decades witnessed significant advances in understanding the molecular mechanisms that underlie TRP channels activation. This review focuses on our current understanding of the molecular determinants for TRP channel activation.

Original languageEnglish (US)
Pages (from-to)221-242
Number of pages22
JournalComprehensive Physiology
Volume3
Issue number1
DOIs
StatePublished - 2013

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Transient Receptor Potential Channels
Smell
Touch
Hearing
Pain
Temperature

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Molecular mechanism of TRP channels. / Zheng, Jie.

In: Comprehensive Physiology, Vol. 3, No. 1, 2013, p. 221-242.

Research output: Contribution to journalArticle

Zheng, Jie. / Molecular mechanism of TRP channels. In: Comprehensive Physiology. 2013 ; Vol. 3, No. 1. pp. 221-242.
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