Molecular mechanics and dynamics of leukocyte recruitment during inflammation

Scott I. Simon, Chad E. Green

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Discovery of new genes and proteins directly supporting leukocyte adhesion is waning, whereas there is heightened interest in the cell mechanics and receptor dynamics that lead from transient tethering via selectins to affinity shifts and adhesion strengthening through integrins. New optical tools enable real-time imaging of leukocyte rolling and arrest in parallel plate flow channels (PPFCs), and detection of single-molecule force spectroscopy provides an inner view of the intercellular adhesive contact region. Leukocyte recruitment during acute inflammation is triggered by ligation of G protein-coupled chemotactic receptors (GPCRs) and clustering of selectins. This, in turn, activates β2-integrin (CD18), which facilitates cell capture and arrest in shear flow. This review provides a conceptual model for the molecular events supporting leukocyte recruitment.

Original languageEnglish (US)
Pages (from-to)151-185
Number of pages35
JournalAnnual Review of Biomedical Engineering
Volume7
DOIs
StatePublished - 2005

Fingerprint

Molecular mechanics
Molecular Dynamics Simulation
Mechanics
Molecular dynamics
Selectins
Leukocytes
Adhesion
Inflammation
Proteins
Integrins
Channel flow
Shear flow
Leukocyte Rolling
Adhesives
Molecular Models
Genes
Spectroscopy
G-Protein-Coupled Receptors
Imaging techniques
Molecules

Keywords

  • Adhesion molecules
  • Integrins
  • Neutrophil
  • Selectins
  • Signal transduction

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

Cite this

Molecular mechanics and dynamics of leukocyte recruitment during inflammation. / Simon, Scott I.; Green, Chad E.

In: Annual Review of Biomedical Engineering, Vol. 7, 2005, p. 151-185.

Research output: Contribution to journalArticle

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