Molecular interactions in surface-assembled monolayers of short double-stranded DNA

Ling Huang; Erkin Seker; James P. Landers; Matthew R. Begley; Marcel Utz

doi:10.1021/la100860d

Molecular interactions in surface-assembled monolayers of short double-stranded DNA

Ling Huang, Erkin Seker, James P. Landers, Matthew R. Begley, Marcel Utz

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We present an experimental study of the energetics of repulsion between end-grafted fragments of double-stranded DNA. The absorption isotherm of thiolated DNA fragments has been measured as a function of DNA chain length as well as the salinity of the surrounding solution. The results are consistent with a simple excluded-volume model of the interaction between neighboring DNA strands.

Original language	English (US)
Pages (from-to)	11574-11580
Number of pages	7
Journal	Langmuir
Volume	26
Issue number	13
DOIs	https://doi.org/10.1021/la100860d
State	Published - Jul 6 2010
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la100860d

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abstract = "We present an experimental study of the energetics of repulsion between end-grafted fragments of double-stranded DNA. The absorption isotherm of thiolated DNA fragments has been measured as a function of DNA chain length as well as the salinity of the surrounding solution. The results are consistent with a simple excluded-volume model of the interaction between neighboring DNA strands.",

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