TY - JOUR
T1 - Molecular evolution of CXC chemokines
T2 - Extant CXC chemokines originate from the CNS
AU - Huising, Mark O.
AU - Stet, René J.M.
AU - Kruiswijk, Corine P.
AU - Savelkoul, Huub F.J.
AU - Verburg-Van Kemenade, B. M.Lidy
PY - 2003/6/1
Y1 - 2003/6/1
N2 - The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. Recent elucidation of the pufferfish genome, a representative of an evolutionary ancient vertebrate class, has enabled analysis of the mammalian CXC chemokine system in a phylogenetic context. Comparison of the phylogenies of vertebrate CXC chemokines revealed that fish and mammals have found different solutions to similar problems, grafted on the same basic structural motif. Phylogenetic analyses showed that the large, highly redundant CXC chemokine family is a very recent phenomenon that is exclusive to higher vertebrates. Moreover, its ancestral role is found within the central nervous system and not within the immune system.
AB - The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. Recent elucidation of the pufferfish genome, a representative of an evolutionary ancient vertebrate class, has enabled analysis of the mammalian CXC chemokine system in a phylogenetic context. Comparison of the phylogenies of vertebrate CXC chemokines revealed that fish and mammals have found different solutions to similar problems, grafted on the same basic structural motif. Phylogenetic analyses showed that the large, highly redundant CXC chemokine family is a very recent phenomenon that is exclusive to higher vertebrates. Moreover, its ancestral role is found within the central nervous system and not within the immune system.
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U2 - 10.1016/S1471-4906(03)00120-0
DO - 10.1016/S1471-4906(03)00120-0
M3 - Review article
C2 - 12810106
AN - SCOPUS:0038120069
VL - 24
SP - 306
EP - 312
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 6
ER -