Molecular epidemiology of Bartonella henselae infection in human immunodeficiency virus-infected patients and their cat contacts, using pulsed-field gel electrophoresis and genotyping

Chao Chin Chang, Bruno B Chomel, Rickie W. Kasten, Jordan W. Tappero, Melissa A. Sanchez, Jane E. Koehler

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Bartonella henselae causes severe disease in immunocompromised individuals. B. henselae was isolated from 12 human immunodeficiency virus (HIV)-infected individuals with bacillary angiomatosis and/or peliosis hepatis and from their 15 cat contacts. Specific associations between the 2 B. henselae genotypes, individual pulsed-field gel electrophoresis (PFGE) patterns, and different clinical syndromes and pathogenicity were investigated. The role of cat contacts as the source of human infection was also examined. Three of the 4 patients with B. henselae genotype I infection, but none of the 8 patients with genotype II infection, had hepatosplenic vascular proliferative lesions (P = .018). Four of 5 human-cat pairs had closely-related PFGE patterns and concordant results by 16S rDNA typing, which strongly suggests that human infection was caused by the cat contact. These results corroborate the major role of cats in the transmission of B. henselae to humans and suggest that B. henselae genotypes may induce different pathological features in HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)1733-1739
Number of pages7
JournalJournal of Infectious Diseases
Volume186
Issue number12
DOIs
StatePublished - Dec 15 2002

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Bartonella Infections
Bartonella henselae
Molecular Epidemiology
Pulsed Field Gel Electrophoresis
Cats
HIV
Genotype
Infection
Peliosis Hepatis
Bacillary Angiomatosis
Ribosomal DNA
Blood Vessels
Virulence

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Molecular epidemiology of Bartonella henselae infection in human immunodeficiency virus-infected patients and their cat contacts, using pulsed-field gel electrophoresis and genotyping. / Chang, Chao Chin; Chomel, Bruno B; Kasten, Rickie W.; Tappero, Jordan W.; Sanchez, Melissa A.; Koehler, Jane E.

In: Journal of Infectious Diseases, Vol. 186, No. 12, 15.12.2002, p. 1733-1739.

Research output: Contribution to journalArticle

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