Abstract
In this study, both endogenous and exogenous N2-hydroxymethyl-dG adducts in nasal DNA of rats exposed to 0.7, 2, 5.8, 9.1, or 15.2 ppm [ 13CD2] formaldehyde for 6 h were quantified by a highly sensitive nano-UPLC-MS/MS method. Our data clearly demonstrated that exogenous formaldehyde DNA adducts form in a highly nonlinear fashion, with a 21.7-fold increase in exposure causing a 286-fold increase in exogenous adducts. The ratio of exogenous/endogenous DNA adducts demonstrated that endogenous DNA adducts dominated at low exposures, comprising more than 99%. In contrast, exogenous adducts were not detectable in the bone marrow of rats exposed to 15.2 ppm [13CD2] formaldehyde.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-161 |
| Number of pages | 3 |
| Journal | Chemical Research in Toxicology |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 18 2011 |
| Externally published | Yes |
ASJC Scopus subject areas
- Toxicology
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Cite this
Lu, K., Moeller, B., Doyle-Eisele, M., McDonald, J., & Swenberg, J. A. (2011). Molecular dosimetry of N 2-Hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chemical Research in Toxicology, 24(2), 159-161. https://doi.org/10.1021/tx1003886