Molecular distribution of zinc in biliary and pancreatic secretions

Bo Lönnerdal, Barbara O. Schneeman, Carl L Keen, Lucille S. Hurley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Rat bile and pancreatic fluid were examined for the presence of low molecular weight zinc complexes. Fluids were collected separately by cannulation, and zinc distribution in collected samples was analyzed by gel filtration on Sephadex G-50. Most of the zinc in bile was associated with low molecular weight zinc complexes; only a small amount of zinc was present in the high molecular weight fraction. In contrast, pancreatic secretions did not contain low molecular weight zinc complexes, but there were considerable amounts of zinc bound to high molecular weight compounds. The addition of zinc to bile resulted in an increased amount of zinc in the low molecular weight fraction, while the addition of zinc to pancreatic fluid resulted primarily in an increase in zinc bound to the high molecular weight components. Like pancreatic fluid, homogenates of pancreatic tissue had no low molecular weight zinc complex. In rats whose bile and pancreatic fluid were removed and not returned into the intestine, the amount of zinc bound to low molecular weight complexes in intestinal homogenates was reduced. This alteration of the molecular distribution of zinc in intestinal homogenates by removal of bile and pancreatic fluid suggests the potential importance of low molecular weight zinc complexes for zinc homeostasis.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalBiological Trace Element Research
Issue number3
StatePublished - Sep 1980


  • bile, zinc in fluids from
  • low molecular weight zinc complexes
  • pancreas, zinc in fluids from
  • zinc complexes, in biliary and pancreatic secretions
  • zinc intestinal absorption
  • Zinc, in bile and pancreatic fluids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Biochemistry, Genetics and Molecular Biology(all)


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