Molecular detection and point-of-care testing in Ebola virus disease and other threats: A new global public health framework to stop outbreaks

Gerald J Kost, William Ferguson, Anh Thu Truong, Jackie Hoe, Daisy Prom, Arirat Banpavichit, Surin Kongpila

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Ultrahigh sensitivity and specificity assays that detect Ebola virus disease or other highly contagious and deadly diseases quickly and successfully upstream in Spatial Care Paths™ can stop outbreaks from escalating into devastating epidemics ravaging communities locally and countries globally. Even had the WHO and CDC responded more quickly and not misjudged the dissemination of Ebola in West Africa and other world regions, mobile rapid diagnostics were, and still are, not readily available for immediate and definitive diagnosis, a stunning strategic flaw that needs correcting worldwide. This article strategizes point-of-care testing for diagnosis, triage, monitoring, recovery and stopping outbreaks in the USA and other countries; reviews Ebola molecular diagnostics, summarizes USA FDA emergency use authorizations and documents why they should not be stop-gaps; and reduces community risk from internal and external infectious disease threats by enabling public health at points of need.

Original languageEnglish (US)
Pages (from-to)1245-1259
Number of pages15
JournalExpert Review of Molecular Diagnostics
Volume15
Issue number10
DOIs
StatePublished - Oct 3 2015

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Keywords

  • Ebola
  • Ebola diagnostic center
  • emergency use authorization
  • facilitated-access self-testing
  • point-ofcare
  • public health resilience
  • ultrahigh sensitivity
  • ultrahigh specificity

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pathology and Forensic Medicine

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