TY - JOUR
T1 - Molecular comparison of retroviruses associated with human and simian AIDS
AU - Bryant, M. L.
AU - Yamamoto, J.
AU - Luciw, Paul A
AU - Munn, R.
AU - Marx, P.
AU - Higgins, J.
AU - Pedersen, Niels C
AU - Levine, A.
AU - Gardner, M. B.
PY - 1985
Y1 - 1985
N2 - Infectious retrovirus(es) associated with the human (LAV, HTLV-III, ARV) and simian (SAIDS-1) acquired immune deficiency syndrome were compared by electron microscopy, immunofluorescence and immunoblotting techniques and by restriction endonuclease mapping of the viral genomes. The extracellular virus particles had similar type D morphology, but intracytoplasmic type A nucleoids were found only in SAIDS virus infected cells. Although the antigens of the three prototype AIDS viruses were similar, no cross-reactivity with the SAIDS virus was detected. Molecular hybridization and restriction enzyme analysis also revealed that the SAIDS and AIDS viruses were genetically unrelated. However, only minor differences, consistent with strain polymorphism, were found between the three AIDS virus isolates. Thus, the retroviruses associated with AIDS in macaques and humans are unique to each species.
AB - Infectious retrovirus(es) associated with the human (LAV, HTLV-III, ARV) and simian (SAIDS-1) acquired immune deficiency syndrome were compared by electron microscopy, immunofluorescence and immunoblotting techniques and by restriction endonuclease mapping of the viral genomes. The extracellular virus particles had similar type D morphology, but intracytoplasmic type A nucleoids were found only in SAIDS virus infected cells. Although the antigens of the three prototype AIDS viruses were similar, no cross-reactivity with the SAIDS virus was detected. Molecular hybridization and restriction enzyme analysis also revealed that the SAIDS and AIDS viruses were genetically unrelated. However, only minor differences, consistent with strain polymorphism, were found between the three AIDS virus isolates. Thus, the retroviruses associated with AIDS in macaques and humans are unique to each species.
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U2 - 10.1002/hon.2900030307
DO - 10.1002/hon.2900030307
M3 - Article
C2 - 2995224
AN - SCOPUS:0022002186
VL - 3
SP - 187
EP - 197
JO - Hematological Oncology
JF - Hematological Oncology
SN - 0278-0232
IS - 3
ER -