Abstract
We determined the nucleotide sequence of the coding region for the phosphoprotein (P) gene of the L strain of rinderpest virus (RPV). The gene encodes two overlapping open reading frames of 1521 and 531 nucleotides. Use of the first ATG would produce a P polypeptide of 507 amino acids, while use of the second ATG would produce a C polypeptide of 177 amino acids. In addition, the insertion of an extra G residue at the editing site generates an alternative mRNA potentially encoding the V protein of RPV). Homology comparisons of the P, C and V proteins among various viruses suggest that RPV is closer to measles virus (MV) than to canine distemper virus (CDV). Alignment of the sequences unique to the V protein revealed that the cysteine residues are well conserved among RPV, MV and CDV, and form a 'zinc finger' like motif.
Original language | English (US) |
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Pages (from-to) | 175-178 |
Number of pages | 4 |
Journal | Virus Genes |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Lapinized strain
- P gene
- Rinderpest virus
ASJC Scopus subject areas
- Virology
- Molecular Biology
- Immunology
- Applied Microbiology and Biotechnology
- Genetics