Molecular cloning and mapping of human Semaphorin F from the Cri-du-chat candidate interval

Andrew D. Simmons, Andreas W. Püschel, John Douglas Mcpherson, Joan Overhauser, Michael Lovett

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Cri-du-chat is a human contiguous gene deletion syndrome resulting from hemizygous deletions of chromosome 5p. Here we describe the isolation from within this interval of the human Semaphorin F (SEMAF) gene, a member of a family of proteins that has been implicated in axonal pathfinding. The human SEMAF gene covers at least 10% of the deleted region and defines a new class within this large gene family characterized by the presence of seven type 1 thrombospondin repeats. Prominent expression of murine semaphorin F (Semaf) was observed in the mouse brain, consistent with a role for semaphorin F as a signaling molecule that guides axons or migrating neuronal precursors during development. The known functions of semaphorins and the interesting pattern of expression for Semaf suggest that haploinsufficiency for SEMAF may disrupt normal brain development and might lead to some of the features of Cri-du-chat.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume242
Issue number3
DOIs
StatePublished - Jan 26 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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