Molecular characterization of the mitochondrial autoantigens in primary biliary cirrhosis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Until 4 years ago, PBC could only be classified as an autoimmune liver disease characterized by biliary obstruction and the presence of high titer of AMA. Using the tools of molecular biology, the molecular structures of the autoantigens as well as the B-cell epitopes have been defined within a relatively short time. However, the mechanism of how these subcellular enzymes become autoantigens is still unclear. Is the antibody response antigen driven or the result of molecular mimicry? With the rapid accumulation of information as well as unique reagents such as cDNA clones, recombinant proteins, monoclonal antibodies, it is possible to address questions on the possible mechanisms by which these mitochondrial proteins can become the target of immune response and how these responses are related to the pathogenesis of PBC. The attainment of these challenging goals and directions will be of substantial value in understanding the role of subcellular molecular interactions in the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)518-527
Number of pages10
JournalImmunologic Research
Volume10
Issue number3-4
DOIs
StatePublished - Dec 1991

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Biliary Liver Cirrhosis
Autoantigens
Molecular Mimicry
B-Lymphocyte Epitopes
Mitochondrial Proteins
Molecular Structure
Autoimmunity
Recombinant Proteins
Autoimmune Diseases
Antibody Formation
Liver Diseases
Molecular Biology
Complementary DNA
Clone Cells
Monoclonal Antibodies
Antigens
Enzymes
Direction compound

ASJC Scopus subject areas

  • Immunology

Cite this

Molecular characterization of the mitochondrial autoantigens in primary biliary cirrhosis. / Leung, Patrick S; Van de Water, Judith A; Coppel, Ross L.; Gershwin, M. Eric.

In: Immunologic Research, Vol. 10, No. 3-4, 12.1991, p. 518-527.

Research output: Contribution to journalArticle

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