Abstract
Purpose of review: The intent of this article is to review and update the critical aspects of the sarcoma molecular paradigm by evaluating the latest discoveries in cell cycle biology as they relate to sarcomagenesis. Recent findings: Oncogenes in the form of growth factor receptors, signal transducers, nuclear oncoproteins, antagonists of apoptosis, and antagonists of tumor suppressors all have effects in the formation of sarcomas. Mutations in tumor suppressors also have been implicated in a variety of mesenchymal neoplasms. Maintenance of genomic integrity is critical to the prevention of the genesis of any cancer. Numerous molecular signatures are being discovered in sarcoma biology, and their significance is discussed. Finally, the reader is advised to appreciate the mechanisms of signal transduction, cell-cell interaction and cytoskeletal genes to gain a sincere appreciation for the complexity of the molecular pathogenesis in sarcomas. Summary: Much has yet to be understood regarding the molecular mechanisms by which a sarcoma is born. Cornerstone to that understanding is a fundamental appreciation for the normal mammalian cell cycle and its aberrancies. Only then can we unlock the knowledge to understand sarcomagenesis and the oncologic process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 456-467 |
| Number of pages | 12 |
| Journal | Current Opinion in Orthopaedics |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2004 |
| Externally published | Yes |
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Keywords
- Cell cycle
- Molecular biology
- Sarcoma
ASJC Scopus subject areas
- Surgery
Cite this
Molecular biology of sarcomas : Update-the cell cycle paradigm. / Randall, R; Lessnick, Stephen L.; Johnson, Brian; Joyner, David E.
In: Current Opinion in Orthopaedics, Vol. 15, No. 6, 01.12.2004, p. 456-467.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular biology of sarcomas
T2 - Update-the cell cycle paradigm
AU - Randall, R
AU - Lessnick, Stephen L.
AU - Johnson, Brian
AU - Joyner, David E.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Purpose of review: The intent of this article is to review and update the critical aspects of the sarcoma molecular paradigm by evaluating the latest discoveries in cell cycle biology as they relate to sarcomagenesis. Recent findings: Oncogenes in the form of growth factor receptors, signal transducers, nuclear oncoproteins, antagonists of apoptosis, and antagonists of tumor suppressors all have effects in the formation of sarcomas. Mutations in tumor suppressors also have been implicated in a variety of mesenchymal neoplasms. Maintenance of genomic integrity is critical to the prevention of the genesis of any cancer. Numerous molecular signatures are being discovered in sarcoma biology, and their significance is discussed. Finally, the reader is advised to appreciate the mechanisms of signal transduction, cell-cell interaction and cytoskeletal genes to gain a sincere appreciation for the complexity of the molecular pathogenesis in sarcomas. Summary: Much has yet to be understood regarding the molecular mechanisms by which a sarcoma is born. Cornerstone to that understanding is a fundamental appreciation for the normal mammalian cell cycle and its aberrancies. Only then can we unlock the knowledge to understand sarcomagenesis and the oncologic process.
AB - Purpose of review: The intent of this article is to review and update the critical aspects of the sarcoma molecular paradigm by evaluating the latest discoveries in cell cycle biology as they relate to sarcomagenesis. Recent findings: Oncogenes in the form of growth factor receptors, signal transducers, nuclear oncoproteins, antagonists of apoptosis, and antagonists of tumor suppressors all have effects in the formation of sarcomas. Mutations in tumor suppressors also have been implicated in a variety of mesenchymal neoplasms. Maintenance of genomic integrity is critical to the prevention of the genesis of any cancer. Numerous molecular signatures are being discovered in sarcoma biology, and their significance is discussed. Finally, the reader is advised to appreciate the mechanisms of signal transduction, cell-cell interaction and cytoskeletal genes to gain a sincere appreciation for the complexity of the molecular pathogenesis in sarcomas. Summary: Much has yet to be understood regarding the molecular mechanisms by which a sarcoma is born. Cornerstone to that understanding is a fundamental appreciation for the normal mammalian cell cycle and its aberrancies. Only then can we unlock the knowledge to understand sarcomagenesis and the oncologic process.
KW - Cell cycle
KW - Molecular biology
KW - Sarcoma
UR - http://www.scopus.com/inward/record.url?scp=8544226270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8544226270&partnerID=8YFLogxK
U2 - 10.1097/01.bco.0000145092.88631.c5
DO - 10.1097/01.bco.0000145092.88631.c5
M3 - Review article
AN - SCOPUS:8544226270
VL - 15
SP - 456
EP - 467
JO - Current Orthopaedic Practice
JF - Current Orthopaedic Practice
SN - 1940-7041
IS - 6
ER -