Molecular biology of prostate cancer

X. B. Shi, P. H. Gumerlock

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Carcinoma of the prostate (CaP) is a very prevalent tumor among men. However thus far, relatively little information is known about the molecular mechanisms involved in the development, progression and metastasis of this disease. This article reviews the current state of knowledge of five selected molecular aspects of human CaP: tumor suppressor genes, metastasis suppressor genes and related biological events (allelic loss and DNA methylation), oncogenes (including growth factors and their receptors), the anti-apoptosis gene BCL2, and the human androgen receptor gene (HAR). Alterations of these genes in structure and expression as well as the frequencies of these molecular events are discussed to synthesize an understanding of documented genetic alterations that occur in CaP and their possible relation to the biology of the disease.

Original languageEnglish (US)
Pages (from-to)318-328
Number of pages11
JournalWorld Journal of Urology
Volume14
Issue number5
StatePublished - 1996

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Prostate
Molecular Biology
Prostatic Neoplasms
Tumor Suppressor Genes
Carcinoma
Genes
Growth Factor Receptors
Loss of Heterozygosity
DNA Methylation
Oncogenes
Disease Progression
Apoptosis
Neoplasm Metastasis
Neoplasms
human AR protein

ASJC Scopus subject areas

  • Urology

Cite this

Shi, X. B., & Gumerlock, P. H. (1996). Molecular biology of prostate cancer. World Journal of Urology, 14(5), 318-328.

Molecular biology of prostate cancer. / Shi, X. B.; Gumerlock, P. H.

In: World Journal of Urology, Vol. 14, No. 5, 1996, p. 318-328.

Research output: Contribution to journalArticle

Shi, XB & Gumerlock, PH 1996, 'Molecular biology of prostate cancer', World Journal of Urology, vol. 14, no. 5, pp. 318-328.
Shi XB, Gumerlock PH. Molecular biology of prostate cancer. World Journal of Urology. 1996;14(5):318-328.
Shi, X. B. ; Gumerlock, P. H. / Molecular biology of prostate cancer. In: World Journal of Urology. 1996 ; Vol. 14, No. 5. pp. 318-328.
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