Molecular biological aspects of alcohol-induced liver disease

R. Arnon, S. D. Esposti, Mark A Zern

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Molecular biological investigations have become a predominant methodology applied to the study of alcohol-induced liver disease. The enzymatic pathways responsible for ethanol metabolism, and their genetic as well as environmental control, have become the focus of detailed investigation. More recently, the significance of cytokines in the pathogenesis of alcohol- induced liver disease has also become a major area of speculation. This review focuses on the advances made in studies of two important enzymes responsible for alcohol metabolism, alcohol dehydrogenase and aldehyde dehydrogenase, as well as the investigation of the proinflammatory and profibrogenic cytokines involved in the process of hepatic fibrogenesis. The quality and quantity of new discoveries made in the field of alcohol-induced liver disease is impressive, especially when one realizes that molecular biological approaches have been employed in this area for only 15 years. However, in most cases the studies have been predominantly descriptive, with little direct relevance to the therapeutics of alcoholism and alcohol- induced organ injury. Because the groundwork has been laid, one hopes that the next 15 years will rectify this failure.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume19
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

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Liver
Liver Diseases
Alcohols
Metabolism
Cytokines
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Alcoholism
Ethanol
Wounds and Injuries
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Molecular biological aspects of alcohol-induced liver disease. / Arnon, R.; Esposti, S. D.; Zern, Mark A.

In: Alcoholism: Clinical and Experimental Research, Vol. 19, No. 1, 1995, p. 247-256.

Research output: Contribution to journalArticle

Arnon, R. ; Esposti, S. D. ; Zern, Mark A. / Molecular biological aspects of alcohol-induced liver disease. In: Alcoholism: Clinical and Experimental Research. 1995 ; Vol. 19, No. 1. pp. 247-256.
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