Molecular Basis of Recovering on Mechanical Circulatory Support

Ali Nsair, David A. Liem, Martin Cadeiras, Richard K. Cheng, Mrudula Allareddy, Murray Kwon, Richard Shemin, Mario C. Deng

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Our insights into different system levels of mechanisms by left ventricular assist device support are increasing and suggest a complex regulatory system of overlapping biological processes. To develop novel decision-making strategies and patient selection criteria, heart failure and reverse cardiac remodeling should be conceptualized and explored by a multifaceted research strategy of transcriptomics, metabolomics, proteomics, molecular biology, and bioinformatics. Knowledge of the molecular mechanisms of reverse cardiac remodeling is in its early stages, and comprehensive reconstruction of the underlying networks is necessary.

Original languageEnglish (US)
Pages (from-to)S57-S62
JournalHeart Failure Clinics
Issue number1 SUPPL.
StatePublished - Jan 1 2014


  • Advanced heart failure
  • Mechanical circulatory support
  • Molecular mechanisms
  • Reverse remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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