Abstract
Primary biliary cirrhosis (PBC), styled as a model autoimmune disease, has a very close association with antibodies to mitochondrial antigens. The cloning of cDNAs for mitochondrial antigens led to their identification as the three enzymes of the 2-oxo-acid dehydrogenase family which includes pyruvate dehydrogenase (PDH). The autoantigen is associated with the E2 subunit of these enzymes. PDH is the 70-74 kDa antigen previously identified by immunoblotting. An immunodominant site (autoepitope) can be mapped to a sequence of PDH-E2 which is the site of attachment of the functionally important lipoic acid prosthetic group. Here, Ian Mackay and Eric Gershwin discuss how autoantigen identification and epitope mapping has now proceeded further in PBC than in other autoimmune diseases, and will allow access to critically important questions on pathogenesis of PBC in particular and autoimmunity in general.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-318 |
| Number of pages | 4 |
| Journal | Immunology Today |
| Volume | 10 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
Cite this
Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis. / Mackay, Ian R.; Gershwin, M. Eric.
In: Immunology Today, Vol. 10, No. 9, 1989, p. 315-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis
AU - Mackay, Ian R.
AU - Gershwin, M. Eric
PY - 1989
Y1 - 1989
N2 - Primary biliary cirrhosis (PBC), styled as a model autoimmune disease, has a very close association with antibodies to mitochondrial antigens. The cloning of cDNAs for mitochondrial antigens led to their identification as the three enzymes of the 2-oxo-acid dehydrogenase family which includes pyruvate dehydrogenase (PDH). The autoantigen is associated with the E2 subunit of these enzymes. PDH is the 70-74 kDa antigen previously identified by immunoblotting. An immunodominant site (autoepitope) can be mapped to a sequence of PDH-E2 which is the site of attachment of the functionally important lipoic acid prosthetic group. Here, Ian Mackay and Eric Gershwin discuss how autoantigen identification and epitope mapping has now proceeded further in PBC than in other autoimmune diseases, and will allow access to critically important questions on pathogenesis of PBC in particular and autoimmunity in general.
AB - Primary biliary cirrhosis (PBC), styled as a model autoimmune disease, has a very close association with antibodies to mitochondrial antigens. The cloning of cDNAs for mitochondrial antigens led to their identification as the three enzymes of the 2-oxo-acid dehydrogenase family which includes pyruvate dehydrogenase (PDH). The autoantigen is associated with the E2 subunit of these enzymes. PDH is the 70-74 kDa antigen previously identified by immunoblotting. An immunodominant site (autoepitope) can be mapped to a sequence of PDH-E2 which is the site of attachment of the functionally important lipoic acid prosthetic group. Here, Ian Mackay and Eric Gershwin discuss how autoantigen identification and epitope mapping has now proceeded further in PBC than in other autoimmune diseases, and will allow access to critically important questions on pathogenesis of PBC in particular and autoimmunity in general.
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U2 - 10.1016/0167-5699(89)90088-1
DO - 10.1016/0167-5699(89)90088-1
M3 - Article
VL - 10
SP - 315
EP - 318
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 9
ER -