Molecular and virologic characteristics of lymphoid malignancies in children with AIDS

Kenneth L. McClain, Charles T. Leach, Hal B. Jenson, Vijay V. Joshi, Bradley H Pollock, Robert E. Hutchison, Sharon B. Murphy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: To characterize AIDS-associated lymphoid malignancies in children. Patients and Methods: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c- myc oncogene abnormalities, and presence of HIV and Epstein-Bart virus. Results: Monoclonal immunoglobulin gene rearrangements were identified in 22 of 23 cases tested, the single exception being one of mucosa-associated lymphoid tissue. Immunoglobulin gene/c-myc translocations were found in 3 of 4 cases of B (surface immunoglobulin-positive)-acute lymphoblastic leukemia, 8 of 11 small noncleaved cell lymphomas, and 1 of 5 large cell lymphomas. Mutations of c-myc were found in 2 of 13 small noncleaved cell lymphomas, 1 of 2 Epstein-Barr virus-positive mucosa-associated lymphoid tissue neoplasms, and 1 of 4 Epstein-Barr virus-negative B-acute lymphoblastic leukemia. Six small noncleaved cell lymphomas, both mucosa-associated lymphoid tissue neoplasms and one of large cell lymphoma had high levels of Epstein-Barr virus in tumor tissue. Hodgkin's disease tissue and B-acute lymphoblastic leukemia tumors were negative for EBV. Proviral HIV-1 was not detected in any tumor. Conclusions: AIDS-associated lymphoid malignancies in children appear to have a different distribution of histologic subtypes than adult HIV- infected individuals, fewer large cell lymphomas occur in children. The small noncleaved cell lymphomas exhibit a lower frequency as well as different locations of c-myc mutations than AIDS-associated small noncleaved cell lymphomas in adults.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalJournal of acquired immune deficiency syndromes (1999)
Volume23
Issue number2
StatePublished - Feb 1 2000
Externally publishedYes

Fingerprint

Acquired Immunodeficiency Syndrome
Non-Hodgkin's Lymphoma
Human Herpesvirus 4
Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
Immunoglobulin Genes
Lymphoid Tissue
Mucous Membrane
AIDS-Related Lymphoma
HIV
B-Cell Leukemia
Immunoglobulin Heavy Chain Genes
Marginal Zone B-Cell Lymphoma
B-Cell Antigen Receptors
Mutation
myc Genes
Gene Rearrangement
Hodgkin Disease
HIV-1

Keywords

  • AIDS-associated lymphomas
  • Children
  • EBV
  • Immunoglobulin gene
  • myc

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

McClain, K. L., Leach, C. T., Jenson, H. B., Joshi, V. V., Pollock, B. H., Hutchison, R. E., & Murphy, S. B. (2000). Molecular and virologic characteristics of lymphoid malignancies in children with AIDS. Journal of acquired immune deficiency syndromes (1999), 23(2), 152-159.

Molecular and virologic characteristics of lymphoid malignancies in children with AIDS. / McClain, Kenneth L.; Leach, Charles T.; Jenson, Hal B.; Joshi, Vijay V.; Pollock, Bradley H; Hutchison, Robert E.; Murphy, Sharon B.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 23, No. 2, 01.02.2000, p. 152-159.

Research output: Contribution to journalArticle

McClain, KL, Leach, CT, Jenson, HB, Joshi, VV, Pollock, BH, Hutchison, RE & Murphy, SB 2000, 'Molecular and virologic characteristics of lymphoid malignancies in children with AIDS', Journal of acquired immune deficiency syndromes (1999), vol. 23, no. 2, pp. 152-159.
McClain, Kenneth L. ; Leach, Charles T. ; Jenson, Hal B. ; Joshi, Vijay V. ; Pollock, Bradley H ; Hutchison, Robert E. ; Murphy, Sharon B. / Molecular and virologic characteristics of lymphoid malignancies in children with AIDS. In: Journal of acquired immune deficiency syndromes (1999). 2000 ; Vol. 23, No. 2. pp. 152-159.
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