Molecular and virologic characteristics of lymphoid malignancies in children with AIDS

Kenneth L. McClain, Charles T. Leach, Hal B. Jenson, Vijay V. Joshi, Bradley H Pollock, Robert E. Hutchison, Sharon B. Murphy

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Purpose: To characterize AIDS-associated lymphoid malignancies in children. Patients and Methods: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c- myc oncogene abnormalities, and presence of HIV and Epstein-Bart virus. Results: Monoclonal immunoglobulin gene rearrangements were identified in 22 of 23 cases tested, the single exception being one of mucosa-associated lymphoid tissue. Immunoglobulin gene/c-myc translocations were found in 3 of 4 cases of B (surface immunoglobulin-positive)-acute lymphoblastic leukemia, 8 of 11 small noncleaved cell lymphomas, and 1 of 5 large cell lymphomas. Mutations of c-myc were found in 2 of 13 small noncleaved cell lymphomas, 1 of 2 Epstein-Barr virus-positive mucosa-associated lymphoid tissue neoplasms, and 1 of 4 Epstein-Barr virus-negative B-acute lymphoblastic leukemia. Six small noncleaved cell lymphomas, both mucosa-associated lymphoid tissue neoplasms and one of large cell lymphoma had high levels of Epstein-Barr virus in tumor tissue. Hodgkin's disease tissue and B-acute lymphoblastic leukemia tumors were negative for EBV. Proviral HIV-1 was not detected in any tumor. Conclusions: AIDS-associated lymphoid malignancies in children appear to have a different distribution of histologic subtypes than adult HIV- infected individuals, fewer large cell lymphomas occur in children. The small noncleaved cell lymphomas exhibit a lower frequency as well as different locations of c-myc mutations than AIDS-associated small noncleaved cell lymphomas in adults.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalJournal of acquired immune deficiency syndromes (1999)
Issue number2
StatePublished - Feb 1 2000
Externally publishedYes


  • AIDS-associated lymphomas
  • Children
  • EBV
  • Immunoglobulin gene
  • myc

ASJC Scopus subject areas

  • Virology
  • Immunology


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