Molecular analysis of Clostridium difficile strains isolated from 18 cases of recurrent Clostridium difficile-associated diarrhea

Yajarayma Tang-Feldman, Susan Mayo, Joseph Silva, Stuart H Cohen

Research output: Contribution to journalArticle

48 Scopus citations


Recurrence of Clostridium difficile-associated diarrhea (CDAD) occurs in 15 to 20% of patients after discontinuation of treatment. Arbitrarily primed PCR was used to investigate the epidemiology of recurrent CDAD in 18 patients. Reinfection with a new strain occurred in 6 of 18 patients (33.3%), while 12 patients relapsed with the original strain shortly after discontinuation of treatment. These data suggest that reinfection with exogenous C. difficile is a common problem and that not all recurrences are due to relapse.

Original languageEnglish (US)
Pages (from-to)3413-3414
Number of pages2
JournalJournal of Clinical Microbiology
Issue number7
StatePublished - Jul 1 2003


ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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