Modulation of vascular inflammation by PPARs

Doris M. Tham, Yi Xin Wang, John C Rutledge

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The activation of cells in atherosclerotic lesions leads to the release of proinflammatory molecules and the onset of a chronic inflammatory response. Recent evidence suggests that peroxisome proliferator-activated receptors (PPARs) exert their anti-inflammatory activities in vascular and immunological cell types such as endothelial cells, vascular smooth muscle cells and monocytes/macrophages. In these cells, PPARs regulate the gene expression of key proteins involved in the vascular inflammation contributing to atherogenesis. By modulating transcription of proinflammatory genes such as cytokines, chemokines, endothelial cell adhesion molecules and metalloproteinases, one can affect the events involved in atherogenesis, such as monocyte/macrophage and lymphocyte recruitment to the arterial wall and foam cell formation. Thus, PPAR agonists have emerged as a potential tool to modulate the inception and progression of atherosclerosis by exerting direct antiinflammatory and antiatherogenic actions at the level of the arterial wall. In this review, we will describe the current understanding of PPARs, the antiinflammatory activities of PPAR agonists and their proposed mechanisms of action.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalDrug News and Perspectives
Volume16
Issue number2
DOIs
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Pharmacology

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