Modulation of murine lymphocyte and macrophage proliferation by parenteral zinc

M. J. Murray, F. D. Wilson, G. L. Fisher, Kent L Erickson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The effects of a single i.p. injection of zinc (0.7, 1.3, 4.0 or 12.0 mg/kg), 24 h prior to sacrifice, on lymphocyte blastogenesis as well as lymphocyte and macrophage progenitor cell proliferation were examined using cells from adult BALB/c mice. Splenic lymphocyte blastogenesis in response to T cell mitogens decreased for mice receiving the highest zinc dosage while responses to B cell mitogens were initially depressed, subsequently increased, and finally declined sharply as the LD50 was approached. Splenic B cell colony formation decreased linearly in relation to zinc dosage with a 50% suppression of colony formation observed at approximately 8.0 mg/kg. In contrast, bone marrow granulocyte-macrophage colonies were enhanced at higher dosages (≥2.5 mg/kg) of zinc. These results indicate that zinc exposure at dosages less than the LD50 can influence lymphocyte blastogenesis and clonal expansion of both B cell and macrophage progenitors.

Original languageEnglish (US)
Pages (from-to)744-749
Number of pages6
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology


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