Modulation of monocyte-macrophage function with α-tocopherol: Implications for atherosclerosis

Sridevi Devaraj, Andrea Harris, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. Monocyte-macrophages are crucial cells in atherogenesis. Several lines of evidence suggest that antioxidants, especially α-tocopherol, have beneficial effects with regard to cardiovascular disease. α-Tocopherol has beneficial effects on cell functions that are pivotal in atherogenesis. α-Tocopherol inhibits platelet aggregation and proinflammatory activity of monocytes. In vitro data also support an effect of α-tocopherol on smooth muscle cell proliferation and endothelial function. Finally, recent data support an effect of α-tocopherol on macrophage function. The mounting evidence from in vitro and in vivo studies provides a sound scientific basis for α-tocopherol supplementation. Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalNutrition Reviews
Issue number1
StatePublished - 2002
Externally publishedYes


  • α-tocopherol
  • Antioxidants
  • Cardiovascular disease
  • Platelet aggregation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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