Modulation of monocyte-macrophage function with α-tocopherol

Implications for atherosclerosis

Sridevi Devaraj, Andrea Harris, Ishwarlal Jialal

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. Monocyte-macrophages are crucial cells in atherogenesis. Several lines of evidence suggest that antioxidants, especially α-tocopherol, have beneficial effects with regard to cardiovascular disease. α-Tocopherol has beneficial effects on cell functions that are pivotal in atherogenesis. α-Tocopherol inhibits platelet aggregation and proinflammatory activity of monocytes. In vitro data also support an effect of α-tocopherol on smooth muscle cell proliferation and endothelial function. Finally, recent data support an effect of α-tocopherol on macrophage function. The mounting evidence from in vitro and in vivo studies provides a sound scientific basis for α-tocopherol supplementation. Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalNutrition Reviews
Volume60
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Tocopherols
atherosclerosis
tocopherols
monocytes
Monocytes
Atherosclerosis
macrophages
Macrophages
atherogenesis
cardiovascular diseases
Cardiovascular Diseases
Western World
platelet aggregation
heart diseases
Primary Prevention
in vivo studies
Secondary Prevention
Platelet Aggregation
smooth muscle
myocytes

Keywords

  • α-tocopherol
  • Antioxidants
  • Cardiovascular disease
  • Platelet aggregation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Modulation of monocyte-macrophage function with α-tocopherol : Implications for atherosclerosis. / Devaraj, Sridevi; Harris, Andrea; Jialal, Ishwarlal.

In: Nutrition Reviews, Vol. 60, No. 1, 2002, p. 8-14.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Harris, Andrea ; Jialal, Ishwarlal. / Modulation of monocyte-macrophage function with α-tocopherol : Implications for atherosclerosis. In: Nutrition Reviews. 2002 ; Vol. 60, No. 1. pp. 8-14.
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