Modulation of microtubule dynamics during the cell cycle

Francis J. McNally

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Microtubule dynamics change dramatically during the cell cycle, but the mechanisms by which these changes occur are unknown. Recent progress has been made in four areas: firstly, in the determination of changes in microtubule turnover and net tubulin polymer levels in vivo; secondly, in the elucidation of mechanisms of regulation of microtubule dynamics by microtubule-associated protein 4; thirdly, in the determination of the mechanisms by which Xenopus microtubule-associated protein regulates microtubule dynamics; and fourthly, in the elucidation of the structural basis of microtubule nucleation by γ tubulin.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Cell Biology


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