Modulation of liver regeneration via myeloid PTEN deficiency

Wen Tao Ma, Yan Jie Jia, Qing Zhi Liu, Yan Qing Yang, Jing Bo Yang, Zhi Bin Zhao, Zhen Ye Yang, Qing Hua Shi, Hong Di Ma, M. Eric Gershwin, Zhe Xiong Lian

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver regeneration. We have focused on these two populations and, in particular, the interplay between them. Importantly, we demonstrate that deletion of the myeloid phosphatase and tensin homolog on chromosome 10 (PTEN) leading to an M2-like polarization of Kupffer cells, which results in decreased activation of NK cells. In addition, PTEN-deficient Kupffer cells secrete additional factors that facilitate the proliferation of hepatocytes. In conclusion, PTEN is critical for inhibiting M2-like polarization of Kupffer cells after partial hepatectomy, resulting in NK cell activation and thus the inhibition of liver regeneration. Furthermore, PTEN reduces growth factor secretion by Kupffer cells. Our results suggest that targeting PTEN on Kupffer cells may be useful in altering liver regeneration in patients undergoing liver resection.

Original languageEnglish (US)
Pages (from-to)e2827
JournalCell death & disease
Volume8
Issue number5
DOIs
StatePublished - May 25 2017

Fingerprint

Liver Regeneration
Kupffer Cells
Natural Killer Cells
Chromosomes, Human, Pair 10
Liver
Hepatectomy
Phosphoric Monoester Hydrolases
Hepatocytes
Intercellular Signaling Peptides and Proteins
Population

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

Cite this

Ma, W. T., Jia, Y. J., Liu, Q. Z., Yang, Y. Q., Yang, J. B., Zhao, Z. B., ... Lian, Z. X. (2017). Modulation of liver regeneration via myeloid PTEN deficiency. Cell death & disease, 8(5), e2827. https://doi.org/10.1038/cddis.2017.47

Modulation of liver regeneration via myeloid PTEN deficiency. / Ma, Wen Tao; Jia, Yan Jie; Liu, Qing Zhi; Yang, Yan Qing; Yang, Jing Bo; Zhao, Zhi Bin; Yang, Zhen Ye; Shi, Qing Hua; Ma, Hong Di; Gershwin, M. Eric; Lian, Zhe Xiong.

In: Cell death & disease, Vol. 8, No. 5, 25.05.2017, p. e2827.

Research output: Contribution to journalArticle

Ma, WT, Jia, YJ, Liu, QZ, Yang, YQ, Yang, JB, Zhao, ZB, Yang, ZY, Shi, QH, Ma, HD, Gershwin, ME & Lian, ZX 2017, 'Modulation of liver regeneration via myeloid PTEN deficiency', Cell death & disease, vol. 8, no. 5, pp. e2827. https://doi.org/10.1038/cddis.2017.47
Ma WT, Jia YJ, Liu QZ, Yang YQ, Yang JB, Zhao ZB et al. Modulation of liver regeneration via myeloid PTEN deficiency. Cell death & disease. 2017 May 25;8(5):e2827. https://doi.org/10.1038/cddis.2017.47
Ma, Wen Tao ; Jia, Yan Jie ; Liu, Qing Zhi ; Yang, Yan Qing ; Yang, Jing Bo ; Zhao, Zhi Bin ; Yang, Zhen Ye ; Shi, Qing Hua ; Ma, Hong Di ; Gershwin, M. Eric ; Lian, Zhe Xiong. / Modulation of liver regeneration via myeloid PTEN deficiency. In: Cell death & disease. 2017 ; Vol. 8, No. 5. pp. e2827.
@article{16b9fb7fb88a402cae6cc23f2fe39799,
title = "Modulation of liver regeneration via myeloid PTEN deficiency",
abstract = "Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver regeneration. We have focused on these two populations and, in particular, the interplay between them. Importantly, we demonstrate that deletion of the myeloid phosphatase and tensin homolog on chromosome 10 (PTEN) leading to an M2-like polarization of Kupffer cells, which results in decreased activation of NK cells. In addition, PTEN-deficient Kupffer cells secrete additional factors that facilitate the proliferation of hepatocytes. In conclusion, PTEN is critical for inhibiting M2-like polarization of Kupffer cells after partial hepatectomy, resulting in NK cell activation and thus the inhibition of liver regeneration. Furthermore, PTEN reduces growth factor secretion by Kupffer cells. Our results suggest that targeting PTEN on Kupffer cells may be useful in altering liver regeneration in patients undergoing liver resection.",
author = "Ma, {Wen Tao} and Jia, {Yan Jie} and Liu, {Qing Zhi} and Yang, {Yan Qing} and Yang, {Jing Bo} and Zhao, {Zhi Bin} and Yang, {Zhen Ye} and Shi, {Qing Hua} and Ma, {Hong Di} and Gershwin, {M. Eric} and Lian, {Zhe Xiong}",
year = "2017",
month = "5",
day = "25",
doi = "10.1038/cddis.2017.47",
language = "English (US)",
volume = "8",
pages = "e2827",
journal = "Cell Death and Disease",
issn = "2041-4889",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Modulation of liver regeneration via myeloid PTEN deficiency

AU - Ma, Wen Tao

AU - Jia, Yan Jie

AU - Liu, Qing Zhi

AU - Yang, Yan Qing

AU - Yang, Jing Bo

AU - Zhao, Zhi Bin

AU - Yang, Zhen Ye

AU - Shi, Qing Hua

AU - Ma, Hong Di

AU - Gershwin, M. Eric

AU - Lian, Zhe Xiong

PY - 2017/5/25

Y1 - 2017/5/25

N2 - Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver regeneration. We have focused on these two populations and, in particular, the interplay between them. Importantly, we demonstrate that deletion of the myeloid phosphatase and tensin homolog on chromosome 10 (PTEN) leading to an M2-like polarization of Kupffer cells, which results in decreased activation of NK cells. In addition, PTEN-deficient Kupffer cells secrete additional factors that facilitate the proliferation of hepatocytes. In conclusion, PTEN is critical for inhibiting M2-like polarization of Kupffer cells after partial hepatectomy, resulting in NK cell activation and thus the inhibition of liver regeneration. Furthermore, PTEN reduces growth factor secretion by Kupffer cells. Our results suggest that targeting PTEN on Kupffer cells may be useful in altering liver regeneration in patients undergoing liver resection.

AB - Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver regeneration. We have focused on these two populations and, in particular, the interplay between them. Importantly, we demonstrate that deletion of the myeloid phosphatase and tensin homolog on chromosome 10 (PTEN) leading to an M2-like polarization of Kupffer cells, which results in decreased activation of NK cells. In addition, PTEN-deficient Kupffer cells secrete additional factors that facilitate the proliferation of hepatocytes. In conclusion, PTEN is critical for inhibiting M2-like polarization of Kupffer cells after partial hepatectomy, resulting in NK cell activation and thus the inhibition of liver regeneration. Furthermore, PTEN reduces growth factor secretion by Kupffer cells. Our results suggest that targeting PTEN on Kupffer cells may be useful in altering liver regeneration in patients undergoing liver resection.

UR - http://www.scopus.com/inward/record.url?scp=85042463627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042463627&partnerID=8YFLogxK

U2 - 10.1038/cddis.2017.47

DO - 10.1038/cddis.2017.47

M3 - Article

C2 - 28542148

AN - SCOPUS:85042463627

VL - 8

SP - e2827

JO - Cell Death and Disease

JF - Cell Death and Disease

SN - 2041-4889

IS - 5

ER -